Radiation-induced liver disease (RILD), often called radiation hepatitis, is a syndrome
characterized by the development of anicteric ascites approximately 2 weeks to 4 months after …

We have attempted to evaluate the degree to which hepatic arterial infusion of 5-fluoro-2′-deoxyuridine
(FdUrd) or 5-fluorouracil produces higher hepatic and lower systemic drug …

Hepatobiliary cancers are highly lethal. In 2008, approximately 21,370 persons in the United
States were estimated to be diagnosed with liver or intrahepatic bile duct cancer and 9520 …

Although it is well known that the tolerance of the liver to external beam irradiation depends
on the volume of liver irradiated, few data exist which quantify this dependence. Therefore, a …

… Concurrent continuous-infusion hepatic arterial floxuridine (0.2 mg/kg/d) was delivered as
described, typically through a percutaneous hepatic arterial catheter placed through the …

RESULTS Two patients had functioning surgically implanted he patic artery catheters which
were used for microsphere administration. The remaining 22patients were treated us ing a …

PURPOSE To attempt to safely escalate the dose of radiation for patients with intrahepatic
cancer, we designed a protocol in which each patient received the maximum possible dose …

Hepatobiliary cancers include a spectrum of invasive carcinomas arising in the liver (hepatocellular
carcinoma), gall bladder, and bile ducts (cholangiocarcinomas). Gallbladder cancer …

There is an urgent need for novel polymeric carriers that can selectively deliver a large dose
of chemotherapeutic agents into hepatic cancer cells to achieve high therapeutic activity …

Hepatic arterial (HA) infusional chemotherapy possesses a number of constraints not found
with systemic chemotherapy. The drug used should have activity in a dose-responsive way …