3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice

…, KP Battaile, S Lovell, S Perlman, WC Groutas… - Science translational …, 2020 - science.org
Pathogenic coronaviruses are a major threat to global public health, as exemplified by severe
acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome …

Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses

…, KR Alliston, KP Battaile, WC Groutas… - Journal of …, 2012 - Am Soc Microbiol
Phylogenetic analysis has demonstrated that some positive-sense RNA viruses can be
classified into the picornavirus-like supercluster, which includes picornaviruses, caliciviruses, …

Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

…, Y Kim, S Perlman, WC Groutas… - Proceedings of the …, 2021 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to be a
serious global public health threat. The 3C-like protease (3CLpro) is a virus protease …

Neutrophil elastase inhibitors

WC Groutas, D Dou, KR Alliston - Expert opinion on therapeutic …, 2011 - Taylor & Francis
Introduction: Chronic obstructive pulmonary disease (COPD) constitutes a worldwide health
problem. There is currently an urgent and unmet need for the development of small …

Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold

WC Groutas, R Kuang, R Venkataraman, JB Epp… - Biochemistry, 1997 - ACS Publications
We describe in this paper the structure-based design of a general class of heterocyclic
mechanism-based inhibitors of the serine proteinases that embody in their structure a novel …

[HTML][HTML] Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor

…, S Weerasekara, DH Hua, WC Groutas… - PLoS …, 2016 - journals.plos.org
Coronaviruses infect animals and humans causing a wide range of diseases. The diversity
of coronaviruses in many mammalian species is contributed by relatively high mutation and …

Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis

…, C Eckstrand, WC Groutas… - Journal of feline …, 2018 - journals.sagepub.com
Objectives The safety and efficacy of the 3C-like protease inhibitor GC376 was tested on a
cohort of client-owned cats with various forms of feline infectious peritonitis (FIP). Methods …

Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element

…, S Perlman, KO Chang, WC Groutas - European journal of …, 2018 - Elsevier
There are currently no approved vaccines or small molecule therapeutics available for the
prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) …

Structure-guided design of conformationally constrained cyclohexane inhibitors of severe acute respiratory syndrome coronavirus-2 3CL protease

…, S Perlman, KO Chang, WC Groutas - Journal of medicinal …, 2021 - ACS Publications
A series of nondeuterated and deuterated dipeptidyl aldehyde and masked aldehyde inhibitors
that incorporate in their structure a conformationally constrained cyclohexane moiety was …

Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses

…, DH Hua, ACG Kankanamalage, WC Groutas… - Journal of …, 2015 - Am Soc Microbiol
Feline infectious peritonitis and virulent, systemic calicivirus infection are caused by certain
types of feline coronaviruses (FCoVs) and feline caliciviruses (FCVs), respectively, and are …