Histone deacetylases are known to play a central role in the regulation of several cellular
properties intimately interlinked with the development and progression of cancer. Consequently…

Purpose Preclinical data suggest a contribution of the immune system to chemotherapy
response. In this study, we investigated the prespecified hypothesis that the presence of a …

It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of
circulating tumor cells (CTCs) found in the blood of patients. However, although the presence of …

Purpose Since the introduction of positron emission tomography (PET) imaging with 68 Ga-PSMA-HBED-CC
(= 68 Ga-DKFZ-PSMA-11), this method has been regarded as a significant …

Purpose Our aim was to analyze and validate the prognostic impact of the novel
International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/…

Objective There is a need to develop and validate biomarkers for treatment response and
survival in tubo-ovarian high-grade serous carcinoma (HGSC). The chemotherapy response …

Although it has long been known that the immune cell composition has a strong prognostic
and predictive value in colorectal cancer (CRC), scoring systems such as the immunoscore (…

Objective. Altered bacterial diversity of the intestinal mucosa-associated microbiota may
reflect the net influence of lifestyle factors associated with the development of chronic …

Purpose: Recently, several studies reported a strong functional link between histone
deacetylases (HDAC) and the development of tumors of the large intestine. However, despite the …

Metabolites are the end products of cellular regulatory processes, and their levels can be
regarded as the ultimate response of biological systems to genetic or environmental changes. …