PhosphoGRID is an online database that curates and houses experimentally verified in vivo
phosphorylation sites in the Saccharomyces cerevisiae proteome ( www.phosphogrid.org ). …

Latent HIV-1 (human immunodeficiency virus-1) provirus is unaffected by current AIDS (acquired
immunodeficiency syndrome) therapies. We show here that chaetocin, an SUV39H1 …

Methods To evaluate the pharmacokinetics, biodistribution, microPET imaging, radiation
dosimetry, and normal tissue toxicity in tumor and non-tumor bearing mice of 89 Zr-…

Insulin growth factor receptor (IGF-1R) is overexpressed in many cancers of epithelial origin,
where it confers enhanced proliferation and resistance to therapies targeted at other …

Purpose Construction of antibody-based, molecular-targeted optical imaging probes requires
the labeling of an antibody with a fluorophore. The most common method for doing this …

In vivo imaging is influenced by the half-life, tissue penetration, biodistribution, and affinity of
the imaging probe. Immunoglobulin G (IgG) is composed of discrete domains with known …

During HIV-1 infection a population of latently infected cells is established. This population
is the major obstacle preventing total eradication of the virus from AIDS patients. HIV-1 …

Epidermal growth factor receptor I (EGFR) is overexpressed in most cancers of epithelial origin.
Antibody drug conjugates (ADCs) with PEGylated-maytansine (PEG-DM1) show promise …

Microbubbles are ultrasound contrast agents that can adhere to disease-related vascular
biomarkers when functionalized with binding ligands such as antibodies or peptides. The biotin…

Highly active antiretroviral therapy ( HAART ) has improved the outlook for the HIV epidemic,
but does not provide a cure. The proposed “shock‐and‐kill” strategy is directed at inducing …