Nitric oxide (NO), a multifaceted bioregulatory agent and an environmental pollutant, can also
cause genomic alterations. In vitro, NO deaminated deoxynucleosides, deoxynucleotides, …

Understanding precisely how the heart can recognize and respond to many different extracellular
signalling molecules, such as neurotransmitters, hormones and growth factors, will aid …

Transgenic mice were created with cardiac-specific overexpression of the β-adrenergic
receptor kinase-1 (βARK1) or a βARK inhibitor. Animals overexpressing βARK1 demonstrated …

Erythropoietin (EPO) has been shown to protect neurons from ischemic stroke, but can also
increase thrombotic events and mortality rates in patients with ischemic heart disease. We …

Rationale: Embryonic stem cells (ESCs) hold great promise for cardiac regeneration but are
susceptible to various concerns. Recently, salutary effects of stem cells have been …

Complementary DNAs were isolated and used to deduce the primary structures of the α 1
and α 2 subunits of the dihydropyridine-sensitive, voltage-dependent calcium channel from …

Heart failure (HF), the leading cause of death in the western world, develops when a cardiac
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It …

Rationale: Coronary artery ligation to induce myocardial infarction (MI) in mice is typically
performed by an invasive and time-consuming approach that requires ventilation and chest …

Heart failure is accompanied by severely impaired β-adrenergic receptor (βAR) function,
which includes loss of βAR density and functional uncoupling of remaining receptors. An …

Hormones and neurotransmitters may mediate common responses through receptors that
couple to the same class of heterotrimeric guanine nucleotide–binding (G) protein. For …