[PDF][PDF] In vitro and in vivo evaluation of iodine-123-Ro 16-0154: a new imaging agent for SPECT investigations of benzodiazepine receptors
…, G Riccabona, I Bangerl, W Hunkeler… - Journal of Nuclear …, 1990 - Soc Nuclear Med
Sodium (@ 23I) iodide in 0.1 N NaOH with a specific activity between 0.2 and 1.5 TBciJmg (0.04-3.7
GBq/ml) was pro duced at PSI. The bromoprecursor (Ro 19-3797) was synthe sized …
GBq/ml) was pro duced at PSI. The bromoprecursor (Ro 19-3797) was synthe sized …
Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists
…, M Bös, H Stadler, P Schnider, W Hunkeler… - Bioorganic & medicinal …, 2006 - Elsevier
The discovery of a novel, achiral pyridine class of potent and orally active neurokinin-1 (NK
1 ) receptor antagonists is described. The evaluation of this class is briefly outlined, leading …
1 ) receptor antagonists is described. The evaluation of this class is briefly outlined, leading …
Ro 15-4513: partial inverse agonism at the BZR and interaction with ethanol
EP Bonetti, WP Burkard, M Gabl, W Hunkeler… - Pharmacology …, 1988 - Elsevier
The imidazobenzodiazepinone derivative Ro 15-4513 has the activity profile of a partial
inverse (low efficacy) agonist at the benzodiazepine receptor (BZR). It reverses central nervous …
inverse (low efficacy) agonist at the benzodiazepine receptor (BZR). It reverses central nervous …
Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors
…, S Ananthan, P Schonholzer, W Hunkeler… - Journal of medicinal …, 1993 - ACS Publications
Pharm. Sec. 1992, 225, 63-68). However, only the putative ethanol antagonist 1 (Ro 15-4513)
displayed modest selectivity for the DI site compared to other “diazepam-sensitive”(DS) …
displayed modest selectivity for the DI site compared to other “diazepam-sensitive”(DS) …
Benzodiazepines, the story of the antagonist flumazenil and of the partial agonist bretazenil
W Hunkeler - Chimia, 1993 - chimia.ch
The story of flumazenil and bretazenil is a typical example of a serendipitious drug discovery.
In 1979 benzodiazepine antagonists were unknown. No one was looking for them, but they …
In 1979 benzodiazepine antagonists were unknown. No one was looking for them, but they …
Corrin Syntheses. Part VI: Corrin Synthesis via A→D Ring Closure. The Construction of A/D‐Secocorrin Chromophore Systems by the 'Sulfide Contraction' Method and the Photochemical …
…, J Gleason, B Pace, L Ellis, W Hunkeler… - Helvetica Chimica …, 2015 - Wiley Online Library
As already extensively discussed in Part I of this series, the ‘climax’ of the studies at the ETH
on the synthesis of corrins was reached with the conception and experimental realization of …
on the synthesis of corrins was reached with the conception and experimental realization of …
[HTML][HTML] Slags as evidence for copper mining above Casaccia, Val Bregaglia (Central Alps)
Slags from the remote Mota Farun locality above Casaccia (Val Bregaglia, Swiss Alps) have
been analyzed with scanning electron microscopy, X-ray powder diffraction and microfocus …
been analyzed with scanning electron microscopy, X-ray powder diffraction and microfocus …
A study of some imidazo[l,5‐a]benzodiazepin‐6‐ones by electron impact mass spectrometry. characterization by tandem mass spectrometry of a distonic fragment ion
…, L Zecca, P Mascaro, W Hunkeler - Organic mass …, 1991 - Wiley Online Library
The mass spectra of several imidazo[l,5‐a]benzodiazepin‐6‐one derivatives of
neuropharmacological significance were determined in order to establish their decomposition paths …
neuropharmacological significance were determined in order to establish their decomposition paths …
[PDF][PDF] Dr. Emilio Kyburz-Haerdi 26 February 1928–20 July 2005
R Imhof, HP Märki, W Froestl, W Hunkeler - Chimia, 2005 - ojs.chimia.ch
Emilio was born in Milano, where he enjoyed eight years in the local Swiss School. Later, he
finished his education in Aarau and started his studies at the ETH in Zurich in autumn 1947. …
finished his education in Aarau and started his studies at the ETH in Zurich in autumn 1947. …
[CITATION][C] A Variation of the Sulfide Contraction Procedure for Synthesis of Corrinoid Systems
E Götschi, W Hunkeler, HJ Wild… - … Edition in English, 1973 - Wiley Online Library
Scheme 1. Method A: 1.0 mol of11 u) or f I h)+ 1.5 mol off2u)+ 1.1 mol of dibenzoyl peroxide
in benzene;< a. 20 C; 24h [2, Ill. Method B: 1.0 mol of flu) or (lh)+ I. 0mol of (bj+ 2.0 mol of K …
in benzene;< a. 20 C; 24h [2, Ill. Method B: 1.0 mol of flu) or (lh)+ I. 0mol of (bj+ 2.0 mol of K …