Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating substances
in patients with early forms of Alzheimer disease (AD), and if so, to examine the extent …

Hydrogen 1 ( 1 H) magnetic resonance (MR) spectroscopy enables noninvasive in vivo
quantification of metabolite concentrations in the brain. Currently, metabolite concentrations are …

Cerebral small vessel disease (SVD) is common during ageing and can present as stroke,
cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently …

Working memory is a temporary storage system under attentional control. It is believed to
play a central role in online processing of complex cognitive information and may also play a …

Introduction Psychogenic non-epileptic seizures (PNES) resemble epileptic seizures, but lack
epileptiform brain activity. Instead, the cause is assumed to be psychogenic. An abnormal …

Objective: As blood–brain barrier (BBB) dysfunction may occur in normal aging but may also
play a pivotal role in the pathophysiology of cerebral small vessel disease (cSVD), we used …

… e , Sau May Wong a c , Paul AM Hofman a c , Saartje Burgmans b c , Frans RJ Verhey b c ,
Walter H. Backes a c … Walter H Backes contributed for analysis support and general support. …

Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …

Cerebral small vessel disease (cSVD) comprises pathological processes of the small vessels
in the brain that may manifest clinically as stroke, cognitive impairment, dementia, or gait …

Background The aim of this systematic review was (1) to identify the brain regions involved in
anxiety in Parkinson's disease (PD) based on neuroimaging studies and (2) to interpret the …