Metabolic reprogramming is implicated in macrophage activation, but the underlying
mechanisms are poorly understood. Here, we demonstrate that the NOTCH1 pathway dictates …

The hypoglycemia seen in the fasting PPARα null mouse is thought to be due to impaired
liver fatty acid β-oxidation. The etiology of hypoglycemia in the PPARα null mouse was …

Patients with traumatic brain injury (TBI) routinely exhibit cerebral glucose uptake in excess
of that expected by the low levels of oxygen consumption and lactate production. This brings …

Hepatic steatosis is associated with increased insulin resistance and tricarboxylic acid (TCA)
cycle flux, but decreased ketogenesis and pyruvate dehydrogenase complex (PDC) flux. …

A 9-yr-old boy is described in whom increased serum T 4 concentration, increased T 3 uptake,
and increased free T 4 index were associated with a euthyroid clinical state with normal …

… WN Paul Lee … Paul Lee analysed and helped to interpret the stable isotope studies.
Yasmeen Rahimi, Nam Ho Jeoung, Paul Lee and Robert Harris wrote the paper. …

A method for determining the site and extent of deuterium (D) labeling of glucose by GC MS
and mass fragmentography was developed. Under chemical and electron impact ionization, …

Pancreatic cancer is characterized as a disease with low survival and high mortality because
of no effective diagnostic and therapeutic strategies available in clinic. Conventional …

Fatty liver is a common feature of both obesity and lipodystrophy, reflecting compromised
adipose tissue function. The lipin-deficient fatty liver dystrophy (fld) mouse is an exception, as …

Tracer-based metabolomics is a systems biology tool that combines advances in tracer
methodology for physiological studies, high throughput “-omics” technologies and constraint …