User profiles for Vladimir P. Torchilin

Vladimir Torchilin

University Professor, Northeastern University
Verified email at neu.edu
Cited by 92252

Structure and design of polymeric surfactant-based drug delivery systems

VP Torchilin - Journal of controlled release, 2001 - Elsevier
The review concentrates on the use of polymeric micelles as pharmaceutical carriers.
Micellization of biologically active substances is a general phenomenon that increases the …

Multifunctional nanocarriers

VP Torchilin - Advanced drug delivery reviews, 2006 - Elsevier
Currently used pharmaceutical nanocarriers, such as liposomes, micelles, nanoemulsions,
polymeric nanoparticles and many others demonstrate a broad variety of useful properties, …

Recent advances with liposomes as pharmaceutical carriers

VP Torchilin - Nature reviews Drug discovery, 2005 - nature.com
Liposomes — microscopic phospholipid bubbles with a bilayered membrane structure —
have received a lot of attention during the past 30 years as pharmaceutical carriers of great …

Drug targeting

VP Torchilin - European Journal of Pharmaceutical Sciences, 2000 - Elsevier
The main problems currently associated with systemic drug administration are: even
biodistribution of pharmaceuticals throughout the body; the lack of drug specific affinity toward a …

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment

…, WG Roberts, L Griffith, VP Torchilin… - Proceedings of the …, 1998 - National Acad Sciences
Novel anti-neoplastic agents such as gene targeting vectors and encapsulated carriers are
quite large (approximately 100–300 nm in diameter). An understanding of the functional size …

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

AL Klibanov, K Maruyama, VP Torchilin, L Huang - FEBS letters, 1990 - Elsevier
Incorporation of dioleoyl N-(monomethoxy polyethyleneglycol succinyl)phosphotidylethanolamine
(PEG-PE) into large unilamellar liposomes composed of egg posphatidylcholine:…

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size

…, D Fukumura, M Leunig, DA Berk, VP Torchilin… - Cancer research, 1995 - AACR
Molecular size is one of the key determinants of transvascular transport of therapeutic agents
in tumors. However, there are no data in the literature on the molecular size dependence of …

Micellar nanocarriers: pharmaceutical perspectives

VP Torchilin - Pharmaceutical research, 2007 - Springer
Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and
hydrophilic shell are currently successfully used as pharmaceutical carriers for water-insoluble …

New developments in liposomal drug delivery

BS Pattni, VV Chupin, VP Torchilin - Chemical reviews, 2015 - ACS Publications
… One-dimensional 31 P NMR has also been used to determine the lamallerity, (172)
specifically, the ratio of the amount of phospholipids in the outer to inner layers. (14) It has been …

Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

VP Torchilin - Nature reviews Drug discovery, 2014 - nature.com
The use of nanoparticulate pharmaceutical drug delivery systems (NDDSs) to enhance the in
vivo effectiveness of drugs is now well established. The development of multifunctional and …