User profiles for Vladimir P. Torchilin
Vladimir TorchilinUniversity Professor, Northeastern University Verified email at neu.edu Cited by 92252 |
Structure and design of polymeric surfactant-based drug delivery systems
VP Torchilin - Journal of controlled release, 2001 - Elsevier
The review concentrates on the use of polymeric micelles as pharmaceutical carriers.
Micellization of biologically active substances is a general phenomenon that increases the …
Micellization of biologically active substances is a general phenomenon that increases the …
Multifunctional nanocarriers
VP Torchilin - Advanced drug delivery reviews, 2006 - Elsevier
Currently used pharmaceutical nanocarriers, such as liposomes, micelles, nanoemulsions,
polymeric nanoparticles and many others demonstrate a broad variety of useful properties, …
polymeric nanoparticles and many others demonstrate a broad variety of useful properties, …
Recent advances with liposomes as pharmaceutical carriers
VP Torchilin - Nature reviews Drug discovery, 2005 - nature.com
Liposomes — microscopic phospholipid bubbles with a bilayered membrane structure —
have received a lot of attention during the past 30 years as pharmaceutical carriers of great …
have received a lot of attention during the past 30 years as pharmaceutical carriers of great …
Drug targeting
VP Torchilin - European Journal of Pharmaceutical Sciences, 2000 - Elsevier
The main problems currently associated with systemic drug administration are: even
biodistribution of pharmaceuticals throughout the body; the lack of drug specific affinity toward a …
biodistribution of pharmaceuticals throughout the body; the lack of drug specific affinity toward a …
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment
…, WG Roberts, L Griffith, VP Torchilin… - Proceedings of the …, 1998 - National Acad Sciences
Novel anti-neoplastic agents such as gene targeting vectors and encapsulated carriers are
quite large (approximately 100–300 nm in diameter). An understanding of the functional size …
quite large (approximately 100–300 nm in diameter). An understanding of the functional size …
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Incorporation of dioleoyl N-(monomethoxy polyethyleneglycol succinyl)phosphotidylethanolamine
(PEG-PE) into large unilamellar liposomes composed of egg posphatidylcholine:…
(PEG-PE) into large unilamellar liposomes composed of egg posphatidylcholine:…
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size
…, D Fukumura, M Leunig, DA Berk, VP Torchilin… - Cancer research, 1995 - AACR
Molecular size is one of the key determinants of transvascular transport of therapeutic agents
in tumors. However, there are no data in the literature on the molecular size dependence of …
in tumors. However, there are no data in the literature on the molecular size dependence of …
Micellar nanocarriers: pharmaceutical perspectives
VP Torchilin - Pharmaceutical research, 2007 - Springer
Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and
hydrophilic shell are currently successfully used as pharmaceutical carriers for water-insoluble …
hydrophilic shell are currently successfully used as pharmaceutical carriers for water-insoluble …
New developments in liposomal drug delivery
BS Pattni, VV Chupin, VP Torchilin - Chemical reviews, 2015 - ACS Publications
… One-dimensional 31 P NMR has also been used to determine the lamallerity, (172)
specifically, the ratio of the amount of phospholipids in the outer to inner layers. (14) It has been …
specifically, the ratio of the amount of phospholipids in the outer to inner layers. (14) It has been …
Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery
VP Torchilin - Nature reviews Drug discovery, 2014 - nature.com
The use of nanoparticulate pharmaceutical drug delivery systems (NDDSs) to enhance the in
vivo effectiveness of drugs is now well established. The development of multifunctional and …
vivo effectiveness of drugs is now well established. The development of multifunctional and …