Technological advances have led to greater use of both structural and functional brain
imaging to assist with the diagnosis of dementia for the increasing numbers of people with …

The devastating effects of the still incurable Alzheimer’s disease (AD) project an ever
increasing shadow of burden on the health care system and society in general. In this ominous …

The authors used 2-(1-{6-[(2-[ 18 F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile
([ 18 F]FDDNP), a hydrophobic radiofluorinated derivative of 2-{1-[6-(dimethylamino)-2…

Background Amyloid senile plaques and tau neurofibrillary tangles are neuropathological
hallmarks of Alzheimer's disease that accumulate in the cortical regions of the brain in persons …

The rapidly rising prevalence and cost of Alzheimer’s disease in recent decades has made
the imaging of amyloid-ß deposits the focus of intense research. Several amyloid imaging …

Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and
widespread cortical neuronal loss ( Selkoe, 2001 ). The “amyloid cascade hypothesis” posits …

FENE, respectively, and apparent Kd values of 1.86 and 71.2 nM for the low-affinity binding
sites. The traditional radioactive binding assays also produced apparent Kd values in the low …

4-[F-18]fluoro-N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-N-(2-pyridinyl)benzamide, a
selective serotonin 1A (5-HT 1A ) molecular imaging probe, was used in conjunction with …

Chronic traumatic encephalopathy (CTE) is an acquired primary tauopathy with a variety of
cognitive, behavioral, and motor symptoms linked to cumulative brain damage sustained …

Objective Mild traumatic brain injury due to contact sports may cause chronic behavioral,
mood, and cognitive disturbances associated with pathological deposition of tau protein found …