To examine the mechanism by which metformin lowers endogenous glucose production in
type 2 diabetic patients, we studied seven type 2 diabetic subjects, with fasting …

Glucagon-like peptide 1 (GLP-1) is potentially a very attractive agent for treating type 2
diabetes. We explored the effect of short-term (1 week) treatment with a GLP-1 derivative, …

Healthy subjects ingested 2H2O and after 14, 22, and 42 h of fasting the enrichments of
deuterium in the hydrogens bound to carbons 2, 5, and 6 of blood glucose and in body water …

Contributions of renal glucose production to whole-body glucose turnover were determined
in healthy individuals by using the arteriovenous balance technique across the kidneys and …

Effects of free fatty acids (FFAs) on endogenous glucose production (EGP) and gluconeogenesis
(GNG) were examined in healthy subjects (n = 6) during stepwise increased Intralipid/…

To determine whether the hepatic insulin resistance of obesity and type 2 diabetes is due to
impaired insulin-induced suppression of glycogenolysis as well as gluconeogenesis, 10 …

A method is introduced for estimating the contribution of gluconeogenesis to glucose
production. 2H2O is administered orally to achieve 0.5% deuterium enrichment in body water. …

OBJECTIVE—To determine the contribution of hepatic insulin resistance to the
pathogenesis of impaired fasting glucose (IFG). RESEARCH DESIGN AND METHODS—Endogenous …

The use of 2 H 2 O in estimating gluconeogenesis’ contribution to glucose production (%GNG)
was examined during progressive fasting in three groups of healthy subjects. One group (…

Contributions of gluconeogenesis to glucose production were determined between 14 to 22
hours into a fast in type 2 diabetics (n = 9) and age-weight-matched controls (n = 7); ages, …