A common strategy to improve the potency of drug candidates is to introduce chemical
functionalities, like hydrogen bond donors or acceptors, at positions where they are able to …

Suppression of the host defense is one of the hallmarks of Yersinia enterocolitica infection.
This enteric pathogen resists phagocytosis and interferes with macrophage functions from an …

The programmed death protein (PD-1) and its ligand (PD-L1) play critical roles in a checkpoint
pathway cancer cells exploit to evade the immune system. A same-day PET imaging …

The tumor immune microenvironment contributes to tumor initiation, progression, and
response to therapy. Among the immune cell subsets that play a role in the tumor …

The lectin jacalin specifically stimulates lymphocytes expressing the CD4 antigen. Recent
studies have also demonstrated that this lectin interacts with CD4, inhibits in vitro HIV infection…

Background HIV-1 can infect and replicate in both CD4 T cells and macrophages. In these
cell types, HIV-1 entry is mediated by the binding of envelope glycoproteins (gp120 and gp41, …

Human lymphocytes expressing the γδ TCR represent a minor T cell subpopulation found in
blood. The majority of these cells express Vγ9Vδ2 determinants and respond to nonpeptidic …

Cancer immunotherapy, unlike traditional cytotoxic chemotherapeutic treatments, engages
the immune system to identify cancer cells and stimulate immune responses. The …

The molecular mechanics Poisson–Boltzmann surface area (MM/PBSA) method was
applied to the study of the protein–protein complex between a camelid single chain variable …

Background. The recent isolation of Brucella microti from the common vole, the red fox, and
the soil raises the possibility of an eventual reemergence of brucellosis in Europe. In this …