BACKGROUND: Exacerbations of asthma are thought to be caused by airflow obstruction
resulting from airway inflammation, bronchospasm, and mucus plugging. Histologic evidence …

Airway distensibility appears to be unaffected by airway smooth muscle (ASM) tone, despite
the influence of ASM tone on the airway diameter-pressure relationship. This discrepancy …

Rapid arterial O 2 desaturation during apnea in the preterm infant has obvious clinical
implications but to date no adequate explanation for why it exists. Understanding the factors …

Rationale: Transformed MUC1 (tMUC1) is a cancer-associated antigen that is overexpressed
in> 90% of triple-negative breast cancers (TNBC), a highly metastatic and aggressive …

The mechanisms underlying not well-controlled (NWC) asthma remain poorly understood,
but accumulating evidence points to peripheral airway dysfunction as a key contributor. The …

Rationale: Regional hypoventilation in bronchoconstricted patients with asthma is spatially
associated with reduced perfusion, which is proposed to result from hypoxic pulmonary …

We describe a method to determine the phase III slope for the purpose of calculating indexes
of ventilation heterogeneity, S acin and S cond , from the multiple breath nitrogen washout …

Rationale: Brief recurrent apneas in preterm infants and adults can precipitate rapid and
severe arterial O 2 desaturation for reasons that remain unclear. Objectives: We tested a …

Background Without aggressive treatment, pulmonary arterial hypertension (PAH) has a 5-year
mortality of approximately 40%. A patient’s response to vasodilators at diagnosis impacts …

Methods We studied five control subjects, four subjects with ePAH, and four subjects with
PAH who underwent intravenous-bolus 13 NN-saline functional PET imaging of pulmonary …