Well-designed randomized trials provide the highest level of scientific evidence to guide clinical
decision making. In chemoradiotherapy of locally advanced squamous cell carcinoma of …

… Valerie Cristina has the following conflict of interest to declare: consulting/advisory
relationships, Merck-Serono, Eli Lilly, Servier, Celgene; travel grants for congress, Bayer, Merck-…

Simple Summary Papillary thyroid cancer (PTC)-desmoid type fibromatosis (DTF) is one of
the rarest variants of PTC. The diagnosis is histological, and detecting a mutation of CTNNB1 …

Purpose Anti-PD-1/PD-L1 blockade can restore tumour-specific T-cell immunity and is an
emerging therapy in non-small-cell lung cancer (NSCLC). We investigated the correlation …

All grade 1056 (80.1) 820 (49.5) 30.6 (27.4 to 33.8)<. 001 Grade 3-4 20 (1.5) 8 (0.5) 1.0 (0.3
to 1.8). 01 a The Holm-Bonferroni correction for multiple testing was applied for primary …

Purpose: Differentiated thyroid cancer (DTC) accounts for approximately 95% of thyroid
carcinomas. In the metastatic RAI-refractory disease, chemotherapy has very limited efficacy and …

Purpose: Debio 1143 is an oral antagonist of inhibitor of apoptosis proteins, which enhances
tumor response with concomitant chemoradiotherapy. Addition of Debio 1143 to cisplatin-…

Phosphodiesterase (PDE) 7 is involved in proinflammatory processes, being widely expressed
both on lymphocytes and on certain brain regions. Specific inhibitors of PDE7 have been …

Background: The strengthening or substitution of intravenous cytotoxic chemotherapy cycles
by oral targeted anticancer therapies, such as protein kinase inhibitors (PKIs), has provided …

Cerebral oximetry using near-infrared spectroscopy (NIRS) provides continuous, noninvasive
assessment of the degree of hemoglobin saturation of the brain tissue. Previous studies …