18F-EF5: a new PET tracer for imaging hypoxia in head and neck cancer
…, O Eskola, P Lindholm, TJ Grönroos… - Journal of nuclear …, 2008 - Soc Nuclear Med
The aim of this study was to evaluate 2-(2-nitro- 1 H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide
(EF5) labeled with 18 F-fluorine to image hypoxia in patients with …
(EF5) labeled with 18 F-fluorine to image hypoxia in patients with …
[HTML][HTML] Inhibiting notch activity in breast cancer stem cells by glucose functionalized nanoparticles carrying γ-secretase inhibitors
…, M Beck, E Özliseli, D Desai, S Landor, T Gronroos… - Molecular Therapy, 2016 - cell.com
Cancer stem cells (CSCs) are a challenge in cancer treatment due to their therapy
resistance. We demonstrated that enhanced Notch signaling in breast cancer promotes self-renewal …
resistance. We demonstrated that enhanced Notch signaling in breast cancer promotes self-renewal …
Comparison of the biodistribution of two hypoxia markers [18F]FETNIM and [18F]FMISO in an experimental mammary carcinoma
T Grönroos, L Bentzen, P Marjamäki, R Murata… - European Journal of …, 2004 - Springer
The first aim of this study was to compare the hypoxia imaging ability of fluorine-18
fluoroerythronitroimidazole ([ 18 F]FETNIM) with that of fluorine-18 fluoromisonimidazole ([ 18 F]…
fluoroerythronitroimidazole ([ 18 F]FETNIM) with that of fluorine-18 fluoromisonimidazole ([ 18 F]…
In Vivo Imaging of Prostate Cancer Using [68Ga]-Labeled Bombesin Analog BAY86-7548
…, I Jambor, J Kemppainen, K Lehtiö, TJ Grönroos… - Clinical cancer …, 2013 - AACR
Purpose: A novel [ 68 Ga]-labeled DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH
2 peptide (BAY86-7548) having high affinity to bombesin …
2 peptide (BAY86-7548) having high affinity to bombesin …
Hypo-and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms
…, S Jin, M Busk, R Borra, TJ Grönroos… - Proceedings of the …, 2011 - National Acad Sciences
A switch from oxidative phosphorylation to glycolysis is frequently observed in cancer cells
and is linked to tumor growth and invasion, but the underpinning molecular mechanisms …
and is linked to tumor growth and invasion, but the underpinning molecular mechanisms …
Blood metabolism of [methyl- 11C]choline; implications for in vivo imaging with positron emission tomography
A Roivainen, S Forsback, T Grönroos… - European journal of …, 2000 - Springer
[ methyl - 11 C]Choline ( 11 C-choline) is a radioligand potentially useful for oncological
positron emission tomography (PET). As a first step towards the development of a kinetic model …
positron emission tomography (PET). As a first step towards the development of a kinetic model …
Lipid Bilayer-Gated Mesoporous Silica Nanocarriers for Tumor-Targeted Delivery of Zoledronic Acid in Vivo
…, J Sandholm, J Lehtimaki, T Gronroos… - Molecular …, 2017 - ACS Publications
Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate used for the treatment of bone
diseases and calcium metabolism. Anticancer activity of ZOL has been established, but its …
diseases and calcium metabolism. Anticancer activity of ZOL has been established, but its …
[HTML][HTML] Extracellular superoxide dismutase is a growth regulatory mediator of tissue injury recovery
…, LE Laatikainen, M Haaparanta-Solin, TJ Gronroos… - Molecular Therapy, 2009 - cell.com
Extracellular superoxide dismutase (SOD3) gene therapy has been shown to attenuate
tissue damages and to improve the recovery of the tissue injuries, but the cellular events …
tissue damages and to improve the recovery of the tissue injuries, but the cellular events …
Imaging of blood flow and hypoxia in head and neck cancer: initial evaluation with [15O] H2O and [18F] fluoroerythronitroimidazole PET
K Lehtiö, V Oikonen, T Grönroos, O Eskola… - Journal of nuclear …, 2001 - Soc Nuclear Med
Hypoxia is a characteristic feature of malignant tumors that should be evaluated before the
start of therapy. F-labeled fluoroerythronitroimidazole (FETNIM) is a possible candidate for …
start of therapy. F-labeled fluoroerythronitroimidazole (FETNIM) is a possible candidate for …
Lumped constant for [18F]fluorodeoxyglucose in skeletal muscles of obese and nonobese humans
…, V Oikonen, T Tolvanen, T Grönroos… - American Journal …, 2000 - journals.physiology.org
Quantitative 2-[ 18 F]fluoro-2-deoxy-d-glucose ([ 18 F]FDG) positron emission tomography (PET)
has been widely used to calculate glucose utilization in skeletal muscle. FDG-PET …
has been widely used to calculate glucose utilization in skeletal muscle. FDG-PET …