User profiles for Toshio Shimizu

Toshio Shimizu

Tokyo Metropolitan Neurological Hospital
Verified email at tmhp.jp
Cited by 3080

The preparation of alkyltrimethylammonium–kanemite complexes and their conversion to microporous materials

T Yanagisawa, T Shimizu, K Kuroda… - Bulletin of the Chemical …, 1990 - academic.oup.com
Single layered polysilicate kanemite (NaHSi 2 O 5 ·3H 2 O) was allowed to react with
alkyltrimethylammonium chloride solutions to form alkyltrimethylammonium–kanemite complexes. …

Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab

…, M Takeda, Y Fujisaka, J Philips, T Shimizu… - Science translational …, 2011 - science.org
Cetuximab, an antibody directed against the epidermal growth factor receptor, is an effective
clinical therapy for patients with colorectal, head and neck, and non–small cell lung cancer, …

Motor cortical disinhibition in the unaffected hemisphere after unilateral cortical stroke

T Shimizu, A Hosaki, T Hino, M Sato, T Komori, S Hirai… - Brain, 2002 - academic.oup.com
Following a hemispheric stroke, various degrees of neuronal reorganization around the lesion
occur immediately after disease onset and thereafter up to several months. These include …

Stormflow generation in steep forested headwaters: a linked hydrogeomorphic paradigm

…, I Hosoda, M Fujieda, T Shimizu - Hydrological …, 2000 - Wiley Online Library
Headwater catchments are sources of sediments, nutrients, and biota for larger streams, yet
the hydrologic pathways that transport these materials remain unclear. Dynamics of …

The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer

T Shimizu, AW Tolcher, KP Papadopoulos… - Clinical Cancer …, 2012 - AACR
Purpose: This study evaluated the clinical relevance of the dual-targeting strategy involving
PI3K/AKT/mTOR and RAF/MEK/ERK pathways. Experimental Design: We investigated safety…

Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system:“waiting for Godot”

…, K Shida, M Ikeda, M Ikeda, M Arai, Y Inoue, T Shimizu… - Immunogenetics, 2003 - Springer
Genome-wide sequence analysis in the invertebrate chordate, Ciona intestinalis, has provided
a comprehensive picture of immune-related genes in an organism that occupies a key …

Feasibility and utility of a panel testing for 114 cancer‐associated genes in a clinical setting: a hospital‐based study

…, K Satomi, A Sukeda, T Hashimoto, T Shimizu… - Cancer …, 2019 - Wiley Online Library
Next‐generation sequencing ( NGS ) of tumor tissue (ie, clinical sequencing) can guide
clinical management by providing information about actionable gene aberrations that have …

Effects of nano-and micro-filler mixture on electrical insulation properties of epoxy based composites

…, F Sawa, T Nakano, T Ozaki, T Shimizu… - … on Dielectrics and …, 2006 - ieeexplore.ieee.org
This paper focuses on the electrical insulation properties of a newly prepared composite
material by nano- and micro-filler mixture. Nano- and micro-filler mixture composites were made …

Early gastric caner: Endoscopie diagnosis of depth of invasion

T Sano, Y Okuyama, O Kobori, T Shimizu… - Digestive diseases and …, 1990 - Springer
In order to decide on a treatment strategy against gastric cancers, an accurate preoperative
evaluation of the depth of cancer invasion is essential. Preoperative endoscopic diagnosis of …

Health claims on functional foods: the Japanese regulations and an international comparison

T Shimizu - Nutrition research reviews, 2003 - cambridge.org
The Japanese scientific academic community defined ‘functional food’ early in the 1980s.
That is, functional foods are those that have three functions. The primary function is nutrition. …