These findings reveal differences in T-cell activation between responders and
nonresponders early into anti-PD-1 treatment, which may impact many facets of immuno-oncology, …

Incorporation of d-amino acids into peptidoglycan is a unique metabolic feature of bacteria.
Since d-amino acids are not metabolic substrates in most mammalian tissues, this difference …

Purpose: We recently identified CD46 as a novel therapeutic target in prostate cancer. In
this study, we developed a CD46-targeted PET radiopharmaceutical, [ 89 Zr]DFO-YS5, and …

Most clinical trials exploring various combinations of chemo- and immunotherapy rely on
serial biopsy to provide information on immune response. The aim of this study was to assess …

Cold-induced thermogenesis in endotherms demands adaptive thermogenesis fueled by
mitochondrial respiration and Ucp1-mediated uncoupling in multilocular brown adipocytes (BAs…

Currently, there exists no accurate, noninvasive clinical imaging method to detect living
bacteria in vivo. Our goal is to provide a positron emission tomography (PET) method to image …

The role of integrins, in particular αv integrins, in regulating insulin resistance is incompletely
understood. We have previously shown that the αvβ5 integrin ligand milk fat globule …

Synthesis of the acetylcholinesterase inhibitor paraoxon (POX) as a carbon-11 positron
emission tomography tracer ([ 11 C]POX) and profiling in live rats is reported. Naïve rats …

Lymphocytes and innate immune cells are key drivers of multiple sclerosis (MS) and are the
main target of MS disease-modifying therapies (DMT). Ex vivo analyses of MS lesions have …

Purpose Tumor necrosis factor alpha (TNFα) drives inflammation and bone degradation in
patients with rheumatoid arthritis (RA). Some RA patients experience a rapid clinical …