Recent developments in PET detector technology

TK Lewellen - Physics in Medicine & Biology, 2008 - iopscience.iop.org
Positron emission tomography (PET) is a tool for metabolic imaging that has been utilized
since the earliest days of nuclear medicine. A key component of such imaging systems is the …

PET-CT image registration in the chest using free-form deformations

…, DR Haynor, H Vesselle, TK Lewellen… - IEEE transactions on …, 2003 - ieeexplore.ieee.org
We have implemented and validated an algorithm for three-dimensional positron emission
tomography transmission-to-computed tomography registration in the chest, using mutual …

Quantifying regional hypoxia in human tumors with positron emission tomography of [18F] fluoromisonidazole: a pretherapy study of 37 patients

…, W Koh, ML Evans, LM Peterson, TK Lewellen… - International Journal of …, 1996 - Elsevier
Purpose: To assess pretreatment hypoxia in a variety of tumors using positron emission
tomography (PET) after injection of the hypoxia-binding radiopharmaceutical [“‘F] …

Imaging of hypoxia in human tumors with [F-18] fluoromisonidazole

…, JS Rasey, ML Evans, JR Grierson, TK Lewellen… - International Journal of …, 1992 - Elsevier
Fluoromisonidazole (FMISO) has been shown to bind selectively to hypoxic cells in vitro and
in vivo at radiobiologically significant oxygen levels. When labeled with the positron emitter …

Time-of-flight PET

TK Lewellen - Seminars in nuclear medicine, 1998 - Elsevier
… Address reprint requests to Tom K. Lewellen, PhD, Division of Nuclear Medicine, University
of Washington Medical Center, 1959 NE Pacific, Seattle, WA 98195-6004. Copyright 9 1998 …

Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18] fluoromisonidazole positron emission tomography

…, JR Grierson, KL Lindsley, TK Lewellen… - International Journal of …, 1995 - Elsevier
Purpose : Recent clinical investigations have shown a strong correlation between pretreatment
tumor hypoxia and poor response to radiotherapy. These observations raise questions …

18F-FDG PET of gliomas at delayed intervals: improved distinction between tumor and normal gray matter

…, JM Link, TK Lewellen, B Lewellen… - Journal of Nuclear …, 2004 - Soc Nuclear Med
We hypothesized that delineation of gliomas from gray matter with 18 F-FDG PET could be
improved by extending the interval between 18 F-FDG administration and PET data …

[PDF][PDF] Carbon-11-thymidine and FDG to measure therapy response

…, M Zheng, B Lewellen, TK Lewellen… - Journal of Nuclear …, 1998 - Soc Nuclear Med
MATERIALS AND METhODS Patients We evaluated six patients (6 men; age range 45—
69yr; mean age 60 yr), four with small cell lung cancer and two with sarcomas. Cancer was …

[PDF][PDF] Performance standards in positron emission tomography

…, EJ Hoffman, TK Lewellen… - Journal of Nuclear …, 1991 - Soc Nuclear Med
It is important to recognize that this paper does not represent an official standard endorsed
by NEMA, since that will requireapprovalofthe NEMA Codes and Stand ards committee of the …

Modeling and incorporation of system response functions in 3-D whole body PET

…, PE Kinahan, TK Lewellen - IEEE transactions on …, 2006 - ieeexplore.ieee.org
Appropriate application of spatially variant system models can correct for degraded resolution
response and mispositioning errors. This paper explores the detector blurring component …