User profiles for Tobias Pukrop
 | Prof. Dr. Tobias PukropProfessor for Medical Oncology Verified email at ukr.de Cited by 6872 |
Macrophages induce invasiveness of epithelial cancer cells via NF-κB and JNK
Tumor-associated macrophages may influence tumor progression, angiogenesis and
invasion. To investigate mechanisms by which macrophages interact with tumor cells, we …
invasion. To investigate mechanisms by which macrophages interact with tumor cells, we …
[HTML][HTML] Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first …
Background Standard treatment for patients with primary CNS lymphoma remains to be
defined. Active therapies are often associated with increased risk of haematological or …
defined. Active therapies are often associated with increased risk of haematological or …
[HTML][HTML] Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in …
Background The International Extranodal Lymphoma Study Group-32 (IELSG32) trial is an
international randomised phase 2 study that addresses two key clinical questions in the …
international randomised phase 2 study that addresses two key clinical questions in the …
Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines
Interactions between neoplastic and stromal cells contribute to tumor progression. Wnt genes,
involved in cell migration and often deregulated in cancers, are attractive candidates to …
involved in cell migration and often deregulated in cancers, are attractive candidates to …
[PDF][PDF] Restricting glycolysis preserves T cell effector functions and augments checkpoint therapy
…, WR Roush, SF Ong, S Warren, T Pukrop… - Cell reports, 2019 - cell.com
Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor
immunosurveillance. Here, we report that melanoma patients with high expression of …
immunosurveillance. Here, we report that melanoma patients with high expression of …
Microglia promote colonization of brain tissue by breast cancer cells in a Wnt‐dependent way
T Pukrop, F Dehghani, HN Chuang, R Lohaus… - Glia, 2010 - Wiley Online Library
Although there is increasing evidence that blood‐derived macrophages support tumor
progression, it is still unclear whether specialized resident macrophages, such as brain microglia, …
progression, it is still unclear whether specialized resident macrophages, such as brain microglia, …
[HTML][HTML] Antagonistic regulation of convergent extension movements in Xenopus by Wnt/β-catenin and Wnt/Ca2+ signaling
Convergent extension movements are the main driving force of Xenopus gastrulation. A fine-tuned
regulation of cadherin-mediated cell–cell adhesion is thought to be required for this …
regulation of cadherin-mediated cell–cell adhesion is thought to be required for this …
Long-term efficacy, safety and neurotolerability of MATRix regimen followed by autologous transplant in primary CNS lymphoma: 7-year results of the IELSG32 …
219 HIV-negative adults ≤70 years with primary CNS lymphoma (PCNSL) were enrolled in
the randomized IELSG32 trial. Enrolled patients were randomly assigned to receive …
the randomized IELSG32 trial. Enrolled patients were randomly assigned to receive …
Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN
…, VM Dhople, L Siam, T Pukrop… - Journal of molecular …, 2015 - academic.oup.com
Tumor cells secrete not only a variety of soluble factors, but also extracellular vesicles that
are known to support the establishment of a favorable tumor niche by influencing the …
are known to support the establishment of a favorable tumor niche by influencing the …
β-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis
…, C Stadelmann, C Binder, T Pukrop - …, 2011 - academic.oup.com
A role of WNT signaling for primary breast cancers of the basal-like subtype and as a predictor
of brain metastasis has been described. However, a responsible WNT ligand has not …
of brain metastasis has been described. However, a responsible WNT ligand has not …