[HTML][HTML] A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins

TG Kapp, F Rechenmacher, S Neubauer, OV Maltsev… - Scientific reports, 2017 - nature.com
Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell
structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. …

αvβ3‐or α5β1‐integrin‐selective peptidomimetics for surface coating

…, S Neubauer, TG Kapp… - Angewandte Chemie …, 2016 - Wiley Online Library
Engineering biomaterials with integrin‐binding activity is a very powerful approach to promote
cell adhesion, modulate cell behavior, and induce specific biological responses at the …

Stable peptides instead of stapled peptides: highly potent αvβ6‐selective integrin ligands

OV Maltsev, UK Marelli, TG Kapp… - Angewandte Chemie …, 2016 - Wiley Online Library
The αvβ6 integrin binds the RGD‐containing peptide of the foot and mouth disease virus
with high selectivity. In this study, the long binding helix of this ligand was downsized to an …

Integrin modulators: a patent review

TG Kapp, F Rechenmacher, TR Sobahi… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Integrins are heterodimeric cell surface receptors, which enable adhesion,
proliferation, and migration of cells by recognizing binding motifs in extracellular matrix (ECM) …

In vivo PET imaging of the cancer integrin αvβ6 using 68Ga-labeled cyclic RGD nonapeptides

J Notni, D Reich, OV Maltsev, TG Kapp… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Expression of the cellular transmembrane receptor αvβ6 integrin is essentially restricted to
malignant epithelial cells in carcinomas of a broad variety of lineages, whereas it is virtually …

Benefits of NOPO As Chelator in Gallium-68 Peptides, Exemplified by Preclinical Characterization of 68Ga-NOPO–c(RGDfK)

J Simecek, J Notni, TG Kapp, H Kessler… - Molecular …, 2014 - ACS Publications
The α v β 3 -integrin addressing cyclic pentapeptide cyclo(RGDfK) was conjugated to NOPO,
1,4,7-triazacyclononane-1,4-bis[methylene(hydroxymethyl)phosphinic acid]-7-[methylene(2…

[HTML][HTML] Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly

…, K Soni, CL Will, D Garg, C Sippel, TG Kapp… - Nature …, 2020 - nature.com
Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a
crucial role in early spliceosome assembly in eukaryotic gene regulation. UHM-ULM …

Selective targeting of integrin αvβ8 by a highly active cyclic peptide

F Reichart, OV Maltsev, TG Kapp… - Journal of medicinal …, 2019 - ACS Publications
Integrins play important roles in physiological and pathophysiological processes. Among
the RGD-recognizing integrin subtypes, the αvβ8 receptor is emerging as an attractive target …

Complementary, selective PET imaging of integrin subtypes α5β1 and αvβ3 using 68Ga-aquibeprin and 68Ga-avebetrin

…, K Steiger, F Hoffmann, D Reich, TG Kapp… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Despite in vivo mapping of integrin α v β 3 expression being thoroughly investigated in recent
years, its clinical value is still not well defined. For imaging of angiogenesis, the integrin …

A Cyclen‐Based Tetraphosphinate Chelator for the Preparation of Radiolabeled Tetrameric Bioconjugates

…, J Havlíčková, E Herdtweck, TG Kapp… - … A European Journal, 2013 - Wiley Online Library
The cyclen‐based tetraphosphinate chelator 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetrakis[methylene(2‐carboxyethyl)phosphinic
acid] (DOTPI) comprises four additional …