Neutrophil extracellular traps (NETs) are extracellular structures composed of chromatin
and granule proteins that bind and kill microorganisms. We show that upon stimulation, the …

Neutrophil extracellular traps (NETs) are part of the innate immune response to infections.
NETs are a meshwork of DNA fibers comprising histones and antimicrobial proteins. Microbes …

Cancer-associated thrombosis often lacks a clear etiology. However, it is linked to a poor
prognosis and represents the second-leading cause of death in cancer patients. Recent …

The granule enzyme myeloperoxidase (MPO) plays an important role in neutrophil antimicrobial
responses. However, the severity of immunodeficiency in patients carrying mutations in …

The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs),
relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils …

Deep vein thrombosis (DVT) is a major health problem that requires improved prophylaxis
and treatment. Inflammatory conditions such as infection, cancer, and autoimmune diseases …

Deep vein thrombosis and pulmonary embolism are major health problems associated with
high mortality. Recently, DNA-based neutrophil extracellular traps (NETs) resulting from the …

Platelet and fibrin clots occlude blood vessels in hemostasis and thrombosis. Here we report
a noncanonical mechanism for vascular occlusion based on neutrophil extracellular traps (…

Deep vein thrombosis (DVT) and its complication, pulmonary embolism, are frequent causes
of disability and mortality. Although blood flow disturbance is considered an important …

Histones are released from dying cells and contribute to antimicrobial defense during infection.
However, extracellular histones are a double-edged sword because they also damage …