Resolution of complex tissue microarchitecture using the diffusion orientation transform (DOT)

E Özarslan, TM Shepherd, BC Vemuri, SJ Blackband… - NeuroImage, 2006 - Elsevier
This article describes an accurate and fast method for fiber orientation mapping using
multidirectional diffusion-weighted magnetic resonance (MR) data. This novel approach utilizes …

Mean apparent propagator (MAP) MRI: a novel diffusion imaging method for mapping tissue microstructure

E Özarslan, CG Koay, TM Shepherd, ME Komlosh… - NeuroImage, 2013 - Elsevier
Diffusion-weighted magnetic resonance (MR) signals reflect information about underlying
tissue microstructure and cytoarchitecture. We propose a quantitative, efficient, and robust …

Aldehyde fixative solutions alter the water relaxation and diffusion properties of nervous tissue

TM Shepherd, PE Thelwall, GJ Stanisz… - … in Medicine: An …, 2009 - Wiley Online Library
Chemically‐fixed nervous tissues are well‐suited for high‐resolution, time‐intensive MRI
acquisitions without motion artifacts, such as those required for brain atlas projects, but the …

In vivo quantification of demyelination and recovery using compartment-specific diffusion MRI metrics validated by electron microscopy

…, A Rajaratnam, NS Kim, JS Babb, TM Shepherd… - Neuroimage, 2016 - Elsevier
There is a need for accurate quantitative non-invasive biomarkers to monitor myelin
pathology in vivo and distinguish myelin changes from other pathological features including …

Postmortem interval alters the water relaxation and diffusion properties of rat nervous tissue—implications for MRI studies of human autopsy samples

TM Shepherd, JJ Flint, PE Thelwall, GJ Stanisz… - Neuroimage, 2009 - Elsevier
High-resolution imaging of human autopsy tissues may improve our understanding of in vivo
MRI findings, but interpretation is complicated because samples are obtained by immersion …

Effects of temperature and aldehyde fixation on tissue water diffusion properties, studied in an erythrocyte ghost tissue model

PE Thelwall, TM Shepherd, GJ Stanisz… - … in Medicine: An …, 2006 - Wiley Online Library
Ex vivo biological sample imaging can complement in vivo MRI studies. Since ex vivo studies
are typically performed at room temperature, and samples are frequently preserved by …

Spatial distribution of multiple sclerosis lesions in the cervical spinal cord

…, TM Shepherd, E Charlson, Y Tachibana, M Hori… - Brain, 2019 - academic.oup.com
Spinal cord lesions detected on MRI hold important diagnostic and prognostic value for
multiple sclerosis. Previous attempts to correlate lesion burden with clinical status have had …

Observation of anomalous diffusion in excised tissue by characterizing the diffusion-time dependence of the MR signal

E Özarslan, PJ Basser, TM Shepherd… - Journal of Magnetic …, 2006 - Elsevier
This report introduces a novel method to characterize the diffusion-time dependence of the
diffusion-weighted magnetic resonance (MR) signal in biological tissues. The approach …

Dixon sequence with superimposed model-based bone compartment provides highly accurate PET/MR attenuation correction of the brain

…, D Faul, FE Boada, TM Shepherd - Journal of Nuclear …, 2016 - Soc Nuclear Med
Simultaneous PET/MR of the brain is a promising technology for characterizing patients with
suspected cognitive impairment or epilepsy. Unlike CT, however, MR signal intensities do …

Functional subclone profiling for prediction of treatment-induced intratumor population shifts and discovery of rational drug combinations in human glioblastoma

…, L Rauschenbach, R Fimmers, TM Shepherd… - Clinical cancer …, 2017 - AACR
Purpose: Investigation of clonal heterogeneity may be key to understanding mechanisms of
therapeutic failure in human cancer. However, little is known on the consequences of …