Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN)
salvage pathway, is an important therapeutic and positron emission tomography (PET) …

Background There is considerable interest in defining the metabolic abnormalities of IDH
mutant tumors to exploit for therapy. While most studies have attempted to discern function by …

Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine
nucleosides. PNP insufficiency in humans is paradoxically associated with both …

Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce
dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic …

Cardiac wound healing following ischemic injury requires a well-described spatiotemporal
progression of events involving multiple cell types and cell-cell interactions. While cellular …

We determine that type I interferon (IFN) response biomarkers are enriched in a subset of
pancreatic ductal adenocarcinoma (PDAC) tumors; however, actionable vulnerabilities …

Functional lysosomes mediate autophagy and macropinocytosis for nutrient acquisition.
Pancreatic ductal adenocarcinoma (PDAC) tumors exhibit high basal lysosomal activity, and …

Prostate-specific membrane antigen (PSMA)–targeted radioligand therapy (RLT) is effective
against prostate cancer (PCa), but all patients relapse eventually. Poor understanding of the …

Pharmacological targeting of metabolic processes in cancer must overcome redundancy in
biosynthetic pathways. Deoxycytidine (dC) triphosphate (dCTP) can be produced both by the …

Host-directed therapy (HDT) is an emerging approach to overcome antimicrobial resistance
in pathogenic microorganisms. Specifically, HDT targets host-encoded factors required for …