Apoptosis, or programmed cell death, is a mechanism by which cells undergo death to
control cell proliferation or in response to DNA damage. The understanding of apoptosis has …

Objectives To evaluate the efficacy of rituximab (RTX) in IgG4-related disease (IgG4-RD) in
an open-label pilot trial. Methods We treated 30 IgG4-RD patients with two doses of RTX (…

The POEMS syndrome (coined to refer to polyneuropathy, organomegaly, endocrinopathy,
M protein, and skin changes) remains poorly understood. Ambiguity exists over the features …

Background There is a paucity of data on long-term management of type 1 autoimmune
pancreatitis (AIP), a relapsing steroid-responsive disorder. Objective We describe our …

Purpose Bleomycin pulmonary toxicity (BPT) has been well described in Hodgkin's lymphoma
(HL) patients treated with bleomycin-containing chemotherapy regimens. The influence of …

Purpose Studies of diffuse large B-cell lymphoma (DLBCL) are typically evaluated by using
a time-to-event approach with relapse, re-treatment, and death commonly used as the events…

We report the results of a phase 2 trial using lenalidomide plus dexamethasone (Rev/Dex)
as initial therapy for myeloma. Thirtyfour patients were enrolled. Lenalidomide was given …

Background In a phase 1 trial, axicabtagene ciloleucel (axi-cel), an autologous anti-CD19
chimeric antigen receptor (CAR) T-cell therapy, showed efficacy in patients with refractory …

… Six years later, William Macintyre described the illness of Thomas Alexander McBean, who
had severe bone pain and at autopsy was found to have cells in the bone marrow consistent …

Background Radiation therapy as an adjunct to surgery for rectal cancer has been shown to
reduce local recurrence but has not improved survival. In a previous study, combined …