The fibrillar peptide amyloid-β (Aβ) has a chief function in the pathogenesis of Alzheimer's
disease. Interleukin 1β (IL-1β) is a key cytokine in the inflammatory response to Aβ. Insoluble …

The tumour microenvironment regulates tumour progression and the spread of cancer in the
body. Targeting the stromal cells that surround cancer cells could, therefore, improve the …

Protein oxidation in vivo is a natural consequence of aerobic life. Oxygen radicals and other
activated oxygen species generated as by‐products of cellular metabolism or from …

Autodigestion of the pancreas by its own prematurely activated digestive proteases is thought
to be an important event in the onset of acute pancreatitis. The mechanism responsible for …

Cathepsins were originally identified as proteases that act in the lysosome. Recent work
has uncovered nontraditional roles for cathepsins in the extracellular space as well as in the …

Multiple types of degradative enzymes, including cathepsins of the cysteine protease family,
have been implicated in the regulation of angiogenesis and invasion during cancer …

The general view on cysteine cathepsins, which were long believed to be primarily involved
in intracellular protein turnover, has dramatically changed in last 10 to 15 years. The …

Complement is viewed as a critical serum-operative component of innate immunity, with
processing of its key component, C3, into activation fragments C3a and C3b confined to the …

Oxidatively modified ferritin is selectively recognized and degraded by the 20S proteasome.
Concentrations of hydrogen peroxide (H 2 O 2 ) higher than 10 µmol/mg of protein are able …

Exposure to various forms of mild oxidative stress significantly increased the intracellular
degradation of both "short-lived" and "long-lived," metabolically radiolabeled, cell proteins in …