User profiles for Theodore S. Lawrence

Theodore S Lawrence

University of Michigan
Verified email at med.umich.edu
Cited by 41763

[BOOK][B] DeVita, Hellman, and Rosenberg's cancer: principles & practice of oncology

VT DeVita, TS Lawrence, SA Rosenberg - 2008 - books.google.com
… This edition is in full color for the first time, has a new editor, Theodore S. Lawrence, MD,
PhD, a radiation oncologist, and has two Associate Scientific Advisors, Ronald A. DePinho, MD …

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

…, H Zhang, W Szeliga, W Gu, R Liu, TS Lawrence… - Nature, 2019 - nature.com
Cancer immunotherapy restores or enhances the effector function of CD8 + T cells in the
tumour microenvironment 1 , 2 . CD8 + T cells activated by cancer immunotherapy clear …

Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

…, K Cuneo, I Kryczek, VT Ma, CD Lao, TS Lawrence… - Nature medicine, 2021 - nature.com
Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to
the liver. It is not clear whether liver immune tolerance mechanisms contribute to cancer …

Analysis of radiation-induced liver disease using the Lyman NTCP model

…, JM Balter, CJ McGinn, TS Lawrence… - International Journal of …, 2002 - Elsevier
Purpose : To describe the dose—volume tolerance for radiation-induced liver disease (RILD)
using the Lyman—Kutcher—Burman (LKB) normal tissue complication probability (NTCP) …

[HTML][HTML] MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells

…, GT Bommer, D Fan, ER Fearon, TS Lawrence… - PloS one, 2009 - journals.plos.org
Background MicroRNAs (miRNAs) have been implicated in cancer initiation and progression
via their ability to affect expression of genes and proteins that regulate cell proliferation and/…

Hepatic toxicity resulting from cancer treatment

TS Lawrence, JM Robertson, MS Anscher… - International Journal of …, 1995 - Elsevier
Radiation-induced liver disease (RILD), often called radiation hepatitis, is a syndrome
characterized by the development of anicteric ascites approximately 2 weeks to 4 months after …

Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response

…, TL Chenevert, TS Lawrence… - Proceedings of the …, 2005 - National Acad Sciences
Assessment of radiation and chemotherapy efficacy for brain cancer patients is traditionally
accomplished by measuring changes in tumor size several months after therapy has been …

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

…, DR Wahl, MA Morgan, AM Chinnaiyan, TS Lawrence… - Cancer discovery, 2019 - AACR
This article describes ferroptosis as a previously unappreciated mechanism of action for
radiotherapy. Further, it shows that ferroptosis is a novel point of synergy between …

[HTML][HTML] Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression

…, AM Chinnaiyan, CD Lao, TS Lawrence… - The Journal of …, 2018 - Am Soc Clin Investig
Programmed death-1 ligand (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1)
pathway blockade is a promising therapy for treating cancer. However, the mechanistic …

Transmission of hormonal stimulation by cell-to-cell communication

TS Lawrence, WH Beers, NB Gilula - Nature, 1978 - nature.com
Rat ovarian granulosa cells and mouse myocardial cells respond to cell-specific hormones
by cyclic AMP-dependent mechanisms. In coculture, these heterologous cells communicate …