[HTML][HTML] Human dectin-1 deficiency and mucocutaneous fungal infections

B Ferwerda, G Ferwerda, TS Plantinga… - … England Journal of …, 2009 - Mass Medical Soc
<p id="p001">Mucocutaneous fungal infections are typically found in patients who have no
known immune defects. We describe a family in which four women who were affected by …

[HTML][HTML] STAT1 Mutations in Autosomal Dominant Chronic Mucocutaneous Candidiasis

FL van de Veerdonk, TS Plantinga… - … England Journal of …, 2011 - Mass Medical Soc
Background Chronic mucocutaneous candidiasis (CMC) is characterized by susceptibility to
candida infection of skin, nails, and mucous membranes. Patients with recessive CMC and …

Modulation of inflammation by autophagy: consequences for human disease

RT Netea-Maier, TS Plantinga, FL van de Veerdonk… - Autophagy, 2016 - Taylor & Francis
Autophagy and inflammation are 2 fundamental biological processes involved in both
physiological and pathological conditions. Through its crucial role in maintaining cellular …

Human TLR10 is an anti-inflammatory pattern-recognition receptor

…, R Vestering-Stenger, TS Plantinga… - Proceedings of the …, 2014 - National Acad Sciences
Toll-like receptor (TLR)10 is the only pattern-recognition receptor without known ligand
specificity and biological function. We demonstrate that TLR10 is a modulatory receptor with …

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

…, MS Gresnigt, J Begun, TS Plantinga… - Proceedings of the …, 2014 - National Acad Sciences
Patients with chronic granulomatous disease (CGD) have a mutated NADPH complex
resulting in defective production of reactive oxygen species; these patients can develop severe …

Early Stop Polymorphism in Human DECTIN-1 Is Associated with Increased Candida Colonization in Hematopoietic Stem Cell Transplant Recipients

TS Plantinga, WJFM Van Der Velden… - Clinical Infectious …, 2009 - academic.oup.com
Background . Intensive treatment of hematological malignancies with hematopoietic stem
cell transplantation (HSCT) is accompanied by a high incidence of opportunistic invasive …

Discovery of common variants associated with low TSH levels and thyroid cancer risk

…, MD Ringel, RT Kloos, MCH De Visser, TS Plantinga… - Nature …, 2012 - nature.com
To search for sequence variants conferring risk of nonmedullary thyroid cancer, we focused
our analysis on 22 SNPs with a P < 5 × 10 −8 in a genome-wide association study on levels …

[HTML][HTML] CX3CR1-dependent renal macrophage survival promotes Candida control and host survival

…, BG Fischer, TS Plantinga… - The Journal of …, 2013 - Am Soc Clin Investig
Systemic Candida albicans infection causes high morbidity and mortality and is associated
with neutropenia; however, the roles of other innate immune cells in pathogenesis are poorly …

[HTML][HTML] Inflammasome-independent modulation of cytokine response by autophagy in human cells

TO Crişan, TS Plantinga, FL van de Veerdonk… - PloS one, 2011 - journals.plos.org
Autophagy is a cell housekeeping mechanism that has recently received attention in relation
to its effects on the immune response. Genetic studies have identified candidate loci for …

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2

TS Plantinga, TO Crisan, M Oosting… - Gut, 2011 - gut.bmj.com
Objective Autophagy has recently been shown to modulate the production of pro-inflammatory
cytokine production and to contribute to antigen processing and presentation through the …