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[HTML][HTML] Super-resolution spectroscopic microscopy via photon localization

B Dong, L Almassalha, BE Urban, TQ Nguyen… - Nature …, 2016 - nature.com
Traditional photon localization microscopy analyses only the spatial distributions of photons
emitted by individual molecules to reconstruct super-resolution optical images. Unfortunately…

Superresolution intrinsic fluorescence imaging of chromatin utilizing native, unmodified nucleic acids for contrast

…, BE Urban, JE Chandler, TQ Nguyen… - Proceedings of the …, 2016 - National Acad Sciences
Visualizing the nanoscale intracellular structures formed by nucleic acids, such as chromatin,
in nonperturbed, structurally and dynamically complex cellular systems, will help expand …

Nanoscale chromatin imaging and analysis platform bridges 4D chromatin organization with molecular function

…, S Jain, G Esteve, JE Chandler, TQ Nguyen… - Science …, 2021 - science.org
Extending across multiple length scales, dynamic chromatin structure is linked to transcription
through the regulation of genome organization. However, no individual technique can fully …

[HTML][HTML] Subsurface super-resolution imaging of unstained polymer nanostructures

BE Urban, B Dong, TQ Nguyen, V Backman, C Sun… - Scientific reports, 2016 - nature.com
Optical imaging has offered unique advantages in material researches, such as spectroscopy
and lifetime measurements of deeply embedded materials, which cannot be matched …

[HTML][HTML] Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging

…, A Eid, G Spicer, LM Almassalha, TQ Nguyen… - Light: Science & …, 2019 - nature.com
Optical coherence tomography angiography relies on motion for contrast and requires at
least two data acquisitions per pointwise scanning location. We present a method termed …

[HTML][HTML] Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis

…, S Courtade-Gaďani, N Provost, TQ Nguyen… - Nature …, 2023 - nature.com
Systemic sclerosis (SSc) is an autoimmune, inflammatory and fibrotic disease with limited
treatment options. Developing new therapies is therefore crucial to address patient needs. To …

Intraoperative Raman spectroscopy of soft tissue sarcomas

JQ Nguyen, ZS Gowani, M O'Connor… - Lasers in surgery …, 2016 - Wiley Online Library
Background and Objective Soft tissue sarcomas (STS) are a rare and heterogeneous group
of malignant tumors that are often treated through surgical resection. Current intraoperative …

Subdiffusion reflectance spectroscopy to measure tissue ultrastructure and microvasculature: model and inverse algorithm

AJ Radosevich, A Eshein, TQ Nguyen… - Journal of biomedical …, 2015 - spiedigitallibrary.org
Reflectance measurements acquired from within the subdiffusion regime (ie, lengthscales
smaller than a transport mean free path) retain much of the original information about the …

Rectal Optical Markers for In Vivo Risk Stratification of Premalignant Colorectal Lesions

AJ Radosevich, NN Mutyal, A Eshein, TQ Nguyen… - Clinical Cancer …, 2015 - AACR
Purpose: Colorectal cancer remains the second leading cause of cancer deaths in the United
States despite being eminently preventable by colonoscopy via removal of premalignant …

[HTML][HTML] Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain

TQ Nguyen, M Chenon, F Vilela, C Velours… - PloS one, 2017 - journals.plos.org
Kinesin1 plays a major role in neuronal transport by recruiting many different cargos
through its kinesin light chain (KLC). Various structurally unrelated cargos interact with the …