User profiles for Tharick Ali Pascoal

Tharick A Pascoal

University of Pittsburgh - pascoal@pitt.edu
Verified email at pitt.edu
Cited by 6811

Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility

…, J Lantero-Rodriguez, TA Pascoal… - Nature Reviews …, 2022 - nature.com
Well-authenticated biomarkers can provide critical insights into the biological basis of
Alzheimer disease (AD) to enable timely and accurate diagnosis, estimate future burden and …

[HTML][HTML] Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease

…, J Therriault, MSP Kang, M Savard, TA Pascoal… - Molecular …, 2021 - Springer
Background Mitochondrial electron transport chain abnormalities have been reported in
postmortem pathological specimens of Alzheimer’s disease (AD). However, it remains unclear …

[HTML][HTML] Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer's pathology

…, S Servaes, J Stevenson, AC Macedo, TA Pascoal… - Ebiomedicine, 2024 - thelancet.com
Background Blood-based biomarkers of Alzheimer's disease (AD) have become increasingly
important as scalable tools for diagnosis and determining clinical trial eligibility. P-tau217 …

Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer's disease

…, MS Kang, M Savard, TA Pascoal… - European journal of …, 2022 - Wiley Online Library
Background and purpose Abnormal mitochondrial metabolism has been described in the
Alzheimer's disease (AD) brain. However, the relationship between AD pathophysiology and …

Race‐related population attributable fraction of preventable risk factors of dementia: a latino population‐based study

…, PL Ferreira, ER Zimmer, TA Pascoal… - Alzheimer's & …, 2023 - Wiley Online Library
Background Risk factors for dementia have distinct frequency and impact in relation to race.
Our aim was to identify differences in modifiable risk factors of dementia related to races and …

Posterior reversible encephalopathy syndrome following a scorpion sting

…, MB Aramburu, LP Schilling, TA Pascoal… - Journal of …, 2013 - Wiley Online Library
Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiologic entity not yet
understood, that is present with transient neurologic symptoms and particular radiological …

[HTML][HTML] Posterior reversible encephalopathy syndrome associated with FOLFOX chemotherapy

…, BF Marrone, TA Pascoal… - Case reports in …, 2013 - hindawi.com
Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiologic entity characterized
by headaches, altered mental status, seizures, visual loss, and characteristic imaging …

Frontal variant of Alzheimer disease differentiated from frontotemporal dementia using in vivo amyloid and tau imaging

V Paquin, J Therriault, TA Pascoal… - Cognitive and …, 2020 - journals.lww.com
The frontal variant of Alzheimer disease (fvAD) is characterized by behavioral and/or
dysexecutive impairments that can resemble those of behavioral-variant frontotemporal dementia (…

[HTML][HTML] Wrappers feature selection in Alzheimer's biomarkers using kNN and SMOTE oversampling

YE Rodrigues, E Manica, ER Zimmer, TA Pascoal… - TEMA (São …, 2017 - SciELO Brasil
Biomarkers are characteristics that are objectively measured and evaluated as an indicator
of normal biological processes, pathogenic processes or pharmacological responses to a …

[HTML][HTML] Dynamic Amyloid and Metabolic Signatures of Delayed Recall Performance within the Clinical Spectrum of Alzheimer's Disease

M Tedeschi Dauar, TA Pascoal, J Therriault, J Rowley… - Brain sciences, 2023 - mdpi.com
Associations between pathophysiological events and cognitive measures provide insights
regarding brain networks affected during the clinical progression of Alzheimer’s disease (AD). …