Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion
…, S Shirabe, M Yamada, H Mizusawa, T Kitamoto… - Nature medicine, 2011 - nature.com
The development of technologies for the in vitro amplification of abnormal conformations of
prion protein (PrP Sc ) has generated the potential for sensitive detection of prions. Here we …
prion protein (PrP Sc ) has generated the potential for sensitive detection of prions. Here we …
Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of …
…, H Sato, F Yoshimasu, T Kitamoto - Journal of …, 2002 - Wiley Online Library
Iron as well as aluminum is reported to accumulate in neurons with neurofibrillary tangles (NFTs)
of Alzheimer's disease (AD) brain. Previously we demonstrated that aluminum (III) …
of Alzheimer's disease (AD) brain. Previously we demonstrated that aluminum (III) …
Quantifying prion disease penetrance using large population control cohorts
…, H Mizusawa, Y Nakamura, T Kitamoto… - Science translational …, 2016 - science.org
More than 100,000 genetic variants are reported to cause Mendelian disease in humans,
but the penetrance—the probability that a carrier of the purported disease-causing genotype …
but the penetrance—the probability that a carrier of the purported disease-causing genotype …
Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease
T Kitamoto, T Muramoto, S Mohri, K Doh-Ura… - Journal of …, 1991 - Am Soc Microbiol
We established that follicular dendritic cells (FDCs) are the site of abnormal prion protein (PrPCJD)
accumulations in lymphoid tissues from mice infected with Creutzfeldt-Jakob disease…
accumulations in lymphoid tissues from mice infected with Creutzfeldt-Jakob disease…
Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.
…, M Porro, F Perini, T Kitamoto… - Proceedings of the …, 1996 - National Acad Sciences
Deposition of PrP amyloid in cerebral vessels in conjunction with neurofibrillary lesions is the
neuropathologic hallmark of the dementia associated with a stop mutation at codon 145 of …
neuropathologic hallmark of the dementia associated with a stop mutation at codon 145 of …
Pro→ Leu change at position 102 of prinon protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndrome
K Doh-ura, J Tateishi, H Sasaki, T Kitamoto… - … and biophysical research …, 1989 - Elsevier
The host-encoded prion protein (PrP) is a component of transmissible amyloid deposited in
the brains affected by Gerstmann-Sträussler syndrome (GSS). Recently GSS in two …
the brains affected by Gerstmann-Sträussler syndrome (GSS). Recently GSS in two …
Prospective 10-year surveillance of human prion diseases in Japan
…, K Sakai, Y Nakamura, T Sato, T Kitamoto… - Brain, 2010 - academic.oup.com
We analysed the epidemiological data and clinical features of patients with prion diseases
that had been registered by the Creutzfeldt-Jakob Disease Surveillance Committee, Japan, …
that had been registered by the Creutzfeldt-Jakob Disease Surveillance Committee, Japan, …
An amber mutation of prion protein in Gerstmann-Sträussler syndrome with mutant PrP plaques
T Kitamoto, R Iizuka, J Tateishi - Biochemical and biophysical research …, 1993 - Elsevier
We found an amber mutation in the open reading frame of the prion protein (PrP) gene. The
codon 145 mutation (tyrosine to stop) was recognized on a PrP allele of a patient with …
codon 145 mutation (tyrosine to stop) was recognized on a PrP allele of a patient with …
Correlations of 18F-THK5351 PET with postmortem burden of tau and astrogliosis in Alzheimer disease
…, R Iwata, M Tashiro, H Sasano, T Kitamoto… - Journal of nuclear …, 2018 - Soc Nuclear Med
Clinical PET studies using 18 F-THK5351 have demonstrated significant tracer retention in
sites susceptible to tau burden in Alzheimer disease (AD). However, the in vivo PET signal to …
sites susceptible to tau burden in Alzheimer disease (AD). However, the in vivo PET signal to …
Codon 219 Lys allele of PRNP is not found in sporadic Creutzfeldt‐Jakob disease
…, J Higuchi, RW Shin, J Tateishi, T Kitamoto - Annals of …, 1998 - Wiley Online Library
The polymorphism at codon 219 of the prion protein gene (PRNP) was found in the general
Japanese population with 6% allele frequency. Herein, we examined 85 cases of sporadic …
Japanese population with 6% allele frequency. Herein, we examined 85 cases of sporadic …