Histone deacetylase 6 (HDAC6), an enzyme involved in protein degradation, exhibits several
unique properties, such as cytoplasmic localization and ubiquitin binding. HDAC6 has …

Abnormal deposition of amyloid-β and hyperphosphorylated tau protein in the brain are the
pathologic hallmark of Alzheimer disease (AD). Noninvasive detection of the lesions is …

Imaging of neurofibrillary pathology in the brain helps in diagnosing dementia, tracking
disease progression, and evaluating the therapeutic efficacy of antidementia drugs. The …

Neurofibrillary tangles in Alzheimer disease (AD) brains are composed of the microtubule-associated
protein tau. Noninvasive monitoring of tau protein aggregates in the living brain …

Clinical PET studies using 18 F-THK5351 have demonstrated significant tracer retention in
sites susceptible to tau burden in Alzheimer disease (AD). However, the in vivo PET signal to …

Purpose Visualization of the spatial distribution of neurofibrillary tangles would help in the
diagnosis, prevention and treatment of dementia. The purpose of the study was to evaluate the …

Purpose Extensive deposition of senile plaques and neurofibrillary tangles in the brain is a
pathological hallmark of Alzheimer’s disease (AD). Although several PET imaging agents …

Tau deposition is one of the neuropathological hallmarks in Alzheimer’s disease as well as
in other neurodegenerative disorders called tauopathies. Recent efforts to develop selective …

The formation of neurofibrillary tangles is believed to contribute to the neurodegeneration
observed in Alzheimer’s disease (AD). Postmortem studies have shown strong associations …

Alzheimer’s disease and other neurodegenerative dementias belong to the family of
tauopathies. These diseases are characterized by the deposition of insoluble tau aggregates …