Epilepsy is one of the most common serious brain conditions, affecting over 70 million people
worldwide. Its incidence has a bimodal distribution with the highest risk in infants and older …

Background Seizure prediction would be clinically useful in patients with epilepsy and could
improve safety, increase independence, and allow acute treatment. We did a multicentre …

Progressive functional decline in the epilepsies is largely unexplained. We formed the
ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, …

The majority of epilepsies are focal in origin, with seizures emanating from one brain region.
Although focal epilepsies often arise from structural brain lesions, many affected individuals …

Objective: To assess efficacy and safety of adjunctive perampanel in patients with drug-resistant,
primary generalized tonic-clonic (PGTC) seizures in idiopathic generalized epilepsy (…

Emerging evidence indicates that epileptic encephalopathies are genetically highly
heterogeneous, underscoring the need for large cohorts of well-characterized individuals to further …

Importance Efficacy of cannabidiol has been demonstrated in seizures associated with
Lennox-Gastaut and Dravet syndromes but appears not yet to have been established in …

Patients with medically intractable partial epilepsy and well-defined symptomatic MRI lesions
were studied using phase-encoded frequency spectral analysis (PEFSA) combined with …

High-fidelity intracranial electrode arrays for recording and stimulating brain activity have
facilitated major advances in the treatment of neurological conditions over the past decade. …

Background The psychotomimetics ketamine and MK-801, non-competitive NMDA receptor (NMDAr)
antagonists, induce cognitive impairment and aggravate schizophrenia symptoms. …