HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
…, JY Melamed, S Young, T Hamill… - Proceedings of the …, 2000 - National Acad Sciences
Diketo acids such as L-731,988 are potent inhibitors of HIV-1 integrase that inhibit integration
and viral replication in cells. These compounds exhibit the unique ability to inhibit the …
and viral replication in cells. These compounds exhibit the unique ability to inhibit the …
[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor
…, S Sanabria-Bohórquez, TG Hamill… - Proceedings of the …, 2007 - National Acad Sciences
[ 18 F]MK-9470 is a selective, high-affinity, inverse agonist (human IC 50 , 0.7 nM) for the
cannabinoid CB1 receptor (CB1R) that has been developed for use in human brain imaging. …
cannabinoid CB1 receptor (CB1R) that has been developed for use in human brain imaging. …
Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers
TG Hamill, S Krause, C Ryan, C Bonnefous, S Govek… - Synapse, 2005 - Wiley Online Library
Three metabotropic glutamate receptor subtype 5 (mGluR5) PET tracers have been labeled
with either carbon‐11 or fluorine‐18 and their in vitro and in vivo behavior in rhesus monkey …
with either carbon‐11 or fluorine‐18 and their in vitro and in vivo behavior in rhesus monkey …
18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: a first-in-human study of radiochemical safety, biokinetics, and radiation …
…, DP Holt, RF Dannals, TG Hamill… - Journal of nuclear …, 2013 - Soc Nuclear Med
Identification of safe and valid PET radioligands for metabotropic glutamate receptor, type 5 (mGluR5),
is essential to measure changes in brain mGluR5 in neuropsychiatric disorders, …
is essential to measure changes in brain mGluR5 in neuropsychiatric disorders, …
Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F] F-PEB
S Patel, TG Hamill, B Connolly, E Jagoda, W Li… - Nuclear medicine and …, 2007 - Elsevier
Binding of [ 18 F]3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ([ 18 F]F-PEB) was evaluated
in membranes and tissue sections prepared from rat, rhesus and human brain. Saturation …
in membranes and tissue sections prepared from rat, rhesus and human brain. Saturation …
Nonpeptide αvβ3 Antagonists. 1. Transformation of a Potent, Integrin-Selective αIIbβ3 Antagonist into a Potent αvβ3 Antagonist
…, LT Duong, JE Fisher, TG Hamill… - Journal of medicinal …, 2000 - ACS Publications
Modification of the potent fibrinogen receptor (α IIb β 3 ) antagonist 1 generated compounds
with high affinity for the vitronectin receptor α v β 3 . Sequential modification of the basic N-…
with high affinity for the vitronectin receptor α v β 3 . Sequential modification of the basic N-…
Visualization and Quantification of Neurokinin-1 (NK1) Receptors in the Human Brain
…, P Lehikoinen, M Goldberg, D Burns, T Hamill… - Molecular imaging and …, 2005 - Springer
Purpose This study was conducted to develop a new positron emission tomography (PET)
method to visualize neurokinin-1 (NK 1 ) receptor systems in the human brain in vivo in order …
method to visualize neurokinin-1 (NK 1 ) receptor systems in the human brain in vivo in order …
Kinetic analysis of the cannabinoid-1 receptor PET tracer [18F]MK-9470 in human brain
SM Sanabria-Bohórquez, TG Hamill, K Goffin… - European journal of …, 2010 - Springer
Purpose Quantitative imaging of the type 1 cannabinoid receptor (CB1R) opens perspectives
for many neurological and psychiatric disorders. We characterized the kinetics and …
for many neurological and psychiatric disorders. We characterized the kinetics and …
An asymmetric total synthesis of fragrant spiro [4.5] decane sesquiterpene (-)-. beta.-vetivone via an enantiomerically pure vinylic sulfoxide
GH Posner, TG Hamill - The Journal of Organic Chemistry, 1988 - ACS Publications
A nonenzymatic asymmetric synthesis of (fi)-(+)-3-methylpentanolide 4 in 93% enantiomeric
purity has been achieved involving novel methyltitanium triisopropoxide conjugate methyl …
purity has been achieved involving novel methyltitanium triisopropoxide conjugate methyl …
Asymmetric michael additions of ester enolates to enantiomerically pure vinylic sulfoxides: synthesis of 3-substituted glutarate esters in high enantiomeric purity
GH Posner, M Weitzberg, TG Hamill, E Asirvatham… - Tetrahedron, 1986 - Elsevier
Various ester enolate ions add as Michael donors to enantiomerically pure Michael acceptor
cycloalkenone sulfoxides 1a and 1b and unsaturated lactone sulfoxides 3a and 3b. The …
cycloalkenone sulfoxides 1a and 1b and unsaturated lactone sulfoxides 3a and 3b. The …