Coronary flow reserve is reduced in young men with IDDM
…, H Iida, TJ Lehtimäki, HK Laine, T Takala… - Diabetes, 1998 - Am Diabetes Assoc
Disturbances of coronary circulation have been reported in diabetic patients with microvascular
complications but without obstructive coronary atherosclerosis. The aim of the present …
complications but without obstructive coronary atherosclerosis. The aim of the present …
Role of blood flow in regulating insulin-stimulated glucose uptake in humans. Studies using bradykinin,[15O] water, and [18F] fluoro-deoxy-glucose and positron …
…, H Laine, O Kirvelä, T Takala… - The Journal of …, 1996 - Am Soc Clin Investig
Defects in insulin stimulation of blood flow have been used suggested to contribute to insulin
resistance. To directly test whether glucose uptake can be altered by changing blood flow, …
resistance. To directly test whether glucose uptake can be altered by changing blood flow, …
Enhanced oxygen extraction and reduced flow heterogeneity in exercising muscle in endurance-trained men
KK Kalliokoski, V Oikonen, TO Takala… - American journal …, 2001 - journals.physiology.org
The aim of this study was to investigate the effects of endurance training on skeletal muscle
hemodynamics and oxygen consumption. Seven healthy endurance-trained and seven …
hemodynamics and oxygen consumption. Seven healthy endurance-trained and seven …
Insulin stimulates liver glucose uptake in humans: an 18F-FDG PET Study
…, F Geisler, V Oikonen, M Mäki, T Takala… - Journal of Nuclear …, 2003 - Soc Nuclear Med
The liver is vital for the regulation of glucose metabolism, but inaccessibility of the organ for
direct assessments has limited the study of its metabolic role in vivo. Methods: The effect of …
direct assessments has limited the study of its metabolic role in vivo. Methods: The effect of …
Myocardial oxygen consumption is unchanged but efficiency is reduced in patients with essential hypertension and left ventricular hypertrophy
…, H Yki-Järvinen, I Kantola, A Jula, TO Takala… - Circulation, 1999 - Am Heart Assoc
Background—Patients with hypertension and left ventricular hypertrophy (LVH) are prone to
develop heart failure. We tested the hypothesis that compensatory LVH is associated with …
develop heart failure. We tested the hypothesis that compensatory LVH is associated with …
Muscle blood flow and flow heterogeneity during exercise studied with positron emission tomography in humans
…, J Kemppainen, K Larmola, TO Takala… - European journal of …, 2000 - Springer
Blood flow is the main regulator of skeletal muscle's oxygen supply, and several studies have
shown heterogeneous blood flow among and within muscles. However, it remains unclear …
shown heterogeneous blood flow among and within muscles. However, it remains unclear …
Single nucleotide polymorphisms in the peroxisome proliferator–activated receptor δ gene are associated with skeletal muscle glucose uptake
…, KA Virtanen, R Lautamäki, P Peltoniemi, T Takala… - Diabetes, 2005 - Am Diabetes Assoc
The peroxisome proliferator–activated receptors (PPARs) belong to a superfamily of nuclear
receptors. It includes PPAR-δ, a key regulator of fatty acid oxidation and energy uncoupling, …
receptors. It includes PPAR-δ, a key regulator of fatty acid oxidation and energy uncoupling, …
Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14 (R, S)-[18F] fluoro-6-thia …
AK Turpeinen, TO Takala, P Nuutila, T Axelin… - Diabetes, 1999 - Am Diabetes Assoc
Free fatty acids (FFAs) are an important substrate for myocardial and skeletal muscle
metabolism, and increased availability and oxidation of FFA are suggested to be associated with …
metabolism, and increased availability and oxidation of FFA are suggested to be associated with …
Insulin action on heart and skeletal muscle glucose uptake in weight lifters and endurance athletes
There are no studies comparing myocardial metabolism between endurance- and
resistance-trained athletes. We used 2-deoxy-2-[ 18 F]fluoro-d-glucose and positron emission …
resistance-trained athletes. We used 2-deoxy-2-[ 18 F]fluoro-d-glucose and positron emission …
14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle
14(R,S)-[ 18 F]Fluoro-6-thia-heptadecanoic acid ([ 18 F]FTHA) is a long-chain fatty acid
substrate for fatty acid metabolism. [ 18 F]FTHA has been used to study fatty acid metabolism in …
substrate for fatty acid metabolism. [ 18 F]FTHA has been used to study fatty acid metabolism in …