A general synthetic route to indenofluorene derivatives as new organic semiconductors

T Hadizad, J Zhang, ZY Wang, TC Gorjanc, C Py - Organic Letters, 2005 - ACS Publications
A series of 2,6-disubstituted indenofluorene derivatives were obtained in high purity via a
general route involving the Suzuki coupling reaction. The potential of these conjugated …

A fast, simple, and reproducible automated synthesis of [18F]FPyKYNE‐c(RGDyK) for αvβ3 receptor positron emission tomography imaging

AC Valdivia, M Estrada, T Hadizad… - Journal of Labelled …, 2012 - Wiley Online Library
[ 18 F]FPyKYNE‐c(RGDyK) was successfully synthesized by the Cu(I) catalyzed Huisgen 1,3‐dipolar
cycloaddition of alkynes to azides using [ 18 F]FPyKYNE as a prosthetic group in …

18F-FDG Cell Labeling May Underestimate Transplanted Cell Homing: More Accurate, Efficient, and Stable Cell Labeling with Hexadecyl-4-[18F]Fluorobenzoate for …

Y Zhang, JN DaSilva, T Hadizad, S Thorn… - Cell …, 2012 - journals.sagepub.com
Cell therapy is expected to restore perfusion and improve function in the ischemic/infarcted
myocardium; however, the biological mechanisms and local effects of transplanted cells …

PET imaging of a collagen matrix reveals its effective injection and targeted retention in a mouse model of myocardial infarction

…, EI Alarcon, M Kordos, DT Padavan, T Hadizad… - Biomaterials, 2015 - Elsevier
Injectable biomaterials have shown promise for cardiac regeneration therapy. However, little
is known regarding their retention and distribution upon application in vivo. Matrix imaging …

Novel O-[11C] methylated derivatives of candesartan as angiotensin II AT1 receptor imaging ligands: Radiosynthesis and ex vivo evaluation in rats

T Hadizad, SA Kirkpatrick, S Mason, K Burns… - Bioorganic & medicinal …, 2009 - Elsevier
[ 11 C]Methyl-candesartan and its desethyl derivative ([ 11 C]TH4) were developed as
potential radiotracers for imaging angiotensin II (Ang II) type 1 (AT 1 ) receptors. These …

Synthesis and evaluation of the novel 2-[18F] fluoro-3-propoxy-triazole-pyridine-substituted losartan for imaging AT1 receptors

N Arksey, T Hadizad, B Ismail, M Hachem… - Bioorganic & Medicinal …, 2014 - Elsevier
The 2-[ 18 F]fluoro-3-pent-4-yn-1-yloxypyridine ([ 18 F]FPyKYNE) analog of the potent non-peptide
angiotensin II type 1 receptor (AT 1 R) blocker losartan was produced via click …

PET imaging of sympathetic innervation with [18F]Flurobenguan vs [11C]mHED in a patient with ischemic cardiomyopathy

…, C Orlandi, S Robinson, T Hadizad… - Journal of Nuclear …, 2019 - Springer
Although reduced ejection fraction defines a high risk subset, most current risk assessment
approaches fail to identify the majority of patients with ischemic cardiomyopathy at risk of …

Characterization of 18F-FPyKYNE-Losartan for imaging AT1 receptors

…, B Ismail, CR Hunter, N Arksey, T Hadizad… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Most physiologic effects of the renin angiotensin system (RAS) are mediated via the angiotensin
(Ang) type 1 receptor (AT 1 R). The 18 F-FPyKYNE derivative of the clinically used AT 1 …

[HTML][HTML] Treatment with enalapril and not diltiazem ameliorated progression of chronic kidney disease in rats, and normalized renal AT1 receptor expression as …

B Ismail, RA deKemp, E Croteau, T Hadizad… - PLoS …, 2017 - journals.plos.org
ACE inhibitors are considered first line of treatment in patients with many forms of chronic
kidney disease (CKD). Other antihypertensives such as calcium channel blockers achieve …

Analysis of [11C] methyl-candesartan kinetics in the rat kidney for the assessment of angiotensin II type 1 receptor density in vivo with PET

M Lortie, JN DaSilva, SA Kirkpatrick, T Hadizad… - Nuclear Medicine and …, 2013 - Elsevier
INTRODUCTION: Angiotensin II type 1 (AT 1 ) receptors play a key role in the regulation of
renal and cardiovascular functions and have been implicated in the pathogenesis of many …