2-Deoxy-2-[ 18 F]fluoro-d-glucose positron emission tomography (FDG-PET) is widely used
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …

Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's
disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a …

BACE1 is the rate-limiting protease in the production of synaptotoxic β-amyloid (Aβ) species
and hence one of the prime drug targets for potential therapy of Alzheimer’s disease (AD). …

Heterozygous missense mutations in the triggering receptor expressed on myeloid cells 2 (TREM2)
have been reported to significantly increase the risk of developing Alzheimer’s …

Background Neuroinflammation has received growing interest as a therapeutic target in
neurodegenerative disorders, including 4‐repeat tauopathies. Objectives The aim of this cross‐…

Nonphysiologic overexpression of amyloid-β (Aβ) precursor protein in common transgenic
Aβ mouse models of Alzheimer disease likely hampers their translational potential. The novel …

Background In vivo assessment of neuroinflammation by 18-kDa translocator protein
positron-emission-tomography (TSPO-PET) ligands receives growing interest in preclinical and …

Background Causal associations between microglia activation and β-amyloid (Aβ) accumulation
during the progression of Alzheimer’s disease (AD) remain a matter of controversy. …

Neuroinflammation may have beneficial or detrimental net effects on the cognitive outcome
of Alzheimer disease (AD) patients. PET imaging with 18-kDa translocator protein (TSPO) …

Beta-site amyloid-precursor-protein cleaving enzyme 1 (BACE1) is the rate limiting protease
in the production of the amyloid-beta peptide (Aβ), which is considered to be the causative …