[64Cu-NOTA-8-Aoc-BBN(7-14)NH2] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues
Radiolabeled peptides hold promise as diagnostic/therapeutic targeting vectors for specific
human cancers. We report the design and development of a targeting vector, [ 64 Cu-NOTA-8…
human cancers. We report the design and development of a targeting vector, [ 64 Cu-NOTA-8…
In vivo evaluation and small-animal PET/CT of a prostate cancer mouse model using 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA …
JC Garrison, TL Rold, GL Sieckman… - Journal of Nuclear …, 2007 - Soc Nuclear Med
The BB2 receptor subtype, of the bombesin family of receptors, has been shown to be highly
overexpressed in a variety of human tumors, including prostate cancer. Bombesin (BBN), a …
overexpressed in a variety of human tumors, including prostate cancer. Bombesin (BBN), a …
Optimization, biological evaluation and microPET imaging of copper-64-labeled bombesin agonists,[64Cu-NO2A-(X)-BBN (7–14) NH2], in a prostate tumor …
SR Lane, P Nanda, TL Rold, GL Sieckman… - Nuclear medicine and …, 2010 - Elsevier
Gastrin-releasing peptide receptors (GRPr) are a member of the bombesin (BBN) receptor
family. GRPr are expressed in high numbers on specific human cancers, including human …
family. GRPr are expressed in high numbers on specific human cancers, including human …
Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis
…, DP Shaw, L Ma, A Brown, T Hoffman, TL Rold… - Cell Cycle, 2010 - Taylor & Francis
Interactions between RNA binding proteins (RBPs) and genes are not well understood,
especially in regulation of angiogenesis. The RBP HuR binds to the AU-rich (ARE) regions of …
especially in regulation of angiogenesis. The RBP HuR binds to the AU-rich (ARE) regions of …
Synthesis and biological evaluation of copper-64 radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN (7-14) NH2], a novel bivalent targeting vector having affinity for …
…, KJ Bassuner, DL Kirkpatrick, TL Rold… - Nuclear medicine and …, 2014 - Elsevier
Gastrin-releasing peptide receptors (GRPr) and prostate-specific membrane antigen (PSMA)
are two identifying biomarkers expressed in very high numbers on prostate cancer cells …
are two identifying biomarkers expressed in very high numbers on prostate cancer cells …
In vitro and in vivo analysis of [64Cu-NO2A-8-Aoc-BBN (7–14) NH2]: a site-directed radiopharmaceutical for positron-emission tomography imaging of T-47D human …
INTRODUCTION: Human breast cancer, from which the T-47D cell line was derived, is known
to overexpress the gastrin-releasing peptide receptor (GRPR) in some cases. Bombesin (…
to overexpress the gastrin-releasing peptide receptor (GRPR) in some cases. Bombesin (…
Design, Synthesis, and Biological Evaluation of an Antagonist− Bombesin Analogue as Targeting Vector
…, F Gallazzi, JC Garrison, TL Rold… - Bioconjugate …, 2008 - ACS Publications
The gastrin releasing peptide receptor (GRP-R) is overexpressed on a number of tumors and
cancer cell lines including pancreas, prostate, breast, gastrointestinal, and small cell lung …
cancer cell lines including pancreas, prostate, breast, gastrointestinal, and small cell lung …
Evaluation of the Pharmacokinetic Effects of Various Linking Group Using the 111In-DOTA-X-BBN(7−14)NH2 Structural Paradigm in a Prostate Cancer Model
JC Garrison, TL Rold, GL Sieckman, F Naz… - Bioconjugate …, 2008 - ACS Publications
The high incidence of BB2 receptor (BB2r) expression in various cancers has prompted
investigators to pursue the development of BB2r-targeted agents for diagnostic imaging, …
investigators to pursue the development of BB2r-targeted agents for diagnostic imaging, …
In Vitro and In Vivo Evaluation of a Novel 99mTc(CO)3-Pyrazolyl Conjugate of cyclo-(Arg-Gly-Asp-d-Tyr-Lys)
S Alves, JDG Correia, L Gano, TL Rold… - Bioconjugate …, 2007 - ACS Publications
Radiolabeled peptides containing the Arg-Gly-Asp amino acid sequence (single letter code
= RGD) have been studied extensively to target integrin receptors upregulated on tumor …
= RGD) have been studied extensively to target integrin receptors upregulated on tumor …
64Cu-NO2A-RGD-Glu-6-Ahx-BBN (7-14) NH2: a heterodimeric targeting vector for positron emission tomography imaging of prostate cancer
AB Jackson, PK Nanda, TL Rold, GL Sieckman… - Nuclear medicine and …, 2012 - Elsevier
INTRODUCTION: The present study describes the design and development of a new
heterodimeric RGD-bombesin (BBN) agonist peptide ligand for dual receptor targeting of the form …
heterodimeric RGD-bombesin (BBN) agonist peptide ligand for dual receptor targeting of the form …