[HTML][HTML] β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection

T Noma, A Lemaire, SVN Prasad… - The Journal of …, 2007 - Am Soc Clin Investig
Acute stimulation of cardiac β1-adrenergic receptors (β1ARs) by norepinephrine represents
the strongest endogenous mechanism for increasing cardiac function, but long-term …

Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model

K Mizushige, L Yao, T Noma, H Kiyomoto, Y Yu… - Circulation, 2000 - Am Heart Assoc
Background—Considerable controversy exists regarding impairment of cardiac function in
diabetes mellitus (DM). We investigated the serial changes in left ventricular (LV) …

[HTML][HTML] Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction

C Perrino, SVN Prasad, L Mao, T Noma… - The Journal of …, 2006 - Am Soc Clin Investig
For over a century, there has been intense debate as to the reason why some cardiac
stresses are pathological and others are physiological. One long-standing theory is that …

Inhibition by eicosapentaenoic acid of oxidized-LDL-and lysophosphatidylcholine-induced human coronary artery smooth muscle cell production of endothelin

…, K Ohmori, Y Wada, I Kondo, T Noma… - Journal of vascular …, 2001 - karger.com
The objectives of the present study were (1) to determine whether oxidized low-density
lipoprotein (LDL) and lysophosphatidylcholine (lyso-PC), a major phospholipid component of …

Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation

K Rafiq, T Noma, Y Fujisawa, Y Ishihara, Y Arai… - Circulation, 2012 - Am Heart Assoc
Background— The presence of chronic kidney disease is a significant independent risk
factor for poor prognosis in patients with chronic heart failure. However, the mechanisms and …

[HTML][HTML] RANKL system in vascular and valve calcification with aging

R Kawakami, H Nakagami, T Noma, K Ohmori… - Inflammation and …, 2016 - Springer
Vascular and cardiac valve calcification is associated with cardiovascular mortality in the
general population. Increasing clinical and experimental evidence suggests that inflammation …

Treatment of acute myocardial infarction by hepatocyte growth factor gene transfer: the first demonstration of myocardial transfer of a “functional” gene using ultrasonic …

…, H Takeuchi, S Fuke, K Shinomiya, T Noma… - Journal of the American …, 2004 - jacc.org
Objectives : We examined whether ultrasonic microbubble destruction (US/MB) enables
therapeutic myocardial gene transfer of hepatocyte growth factor (HGF) for acute myocardial …

[HTML][HTML] Visit-to-visit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients

…, K Murao, M Inukai, N Hosomi, Y Iwado, T Noma… - Hypertension …, 2011 - nature.com
Although visit-to-visit variability in systolic blood pressure (SBP) has recently been demonstrated
to be a strong predictor of stroke, there are no data about relationships between SBP …

Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes

…, I Tsukamoto, T Uyama, Y Ishihara, T Noma… - Molecular and cellular …, 2015 - Elsevier
Vascular endothelial growth factor-A (VEGF-A) released from adipocytes promotes angiogenesis;
and thereby ameliorates the local hypoxia-induced adipose inflammation and insulin …

[HTML][HTML] Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice

…, S Yoshida, J Sun, T Kawano, Y Takami, T Noma… - PloS one, 2018 - journals.plos.org
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates expression of low-density
lipoprotein (LDL) receptors via receptor internalization and subsequent lysosomal degradation…