PET imaging–based evaluation of hepatobiliary transport in humans with (15R)-11C-TIC-Me
T Takashima, S Kitamura, Y Wada… - Journal of Nuclear …, 2012 - Soc Nuclear Med
It is well accepted that drug transporters play a pivotal role in hepatobiliary excretion of anionic
drugs, in which drug–drug interactions and genetic polymorphisms are known to cause …
drugs, in which drug–drug interactions and genetic polymorphisms are known to cause …
In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester
M Shukuri, M Takashima-Hirano… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Cyclooxygenase (COX)-1 and -2 are prostanoid-synthesizing enzymes that play important
roles in the regulation of neuroinflammation and in the development of neurodegenerative …
roles in the regulation of neuroinflammation and in the development of neurodegenerative …
mRNA Expression and Transport Characterization of Conditionally Immortalized Rat Brain Capillary Endothelial Cell Lines; a New in vitro BBB Model for Drug …
KI Hosoya, T Takashima, K Tetsuka… - Journal of drug …, 2000 - Taylor & Francis
Brain capillary endothelial cell lines (TR-BBB) were established from a recently developed
transgenic rat harboring temperature-sensitive simian virus 40 (ts SV 40) large T-antigen …
transgenic rat harboring temperature-sensitive simian virus 40 (ts SV 40) large T-antigen …
Effect of cyclosporin A and impact of dose staggering on OATP1B1/1B3 endogenous substrates and drug probes for assessing clinical drug interactions
…, X Chu, Y Lai, T Takashima… - Clinical …, 2022 - Wiley Online Library
This study was designed to assess the quantitative performance of endogenous biomarkers
for organic anion transporting polypeptide (OATP) 1B1/1B3‐mediated drug‐drug …
for organic anion transporting polypeptide (OATP) 1B1/1B3‐mediated drug‐drug …
Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography tracer [11C] dehydropravastatin in rats
T Shingaki, T Takashima, R Ijuin, X Zhang… - … of Pharmacology and …, 2013 - ASPET
… by rifampicin at the dose examined was also suggested by the use of another PET ligand,
15R-[ 11 C]TIC, the biliary excretion of which was also mainly mediated by Mrp2 (Takashima …
15R-[ 11 C]TIC, the biliary excretion of which was also mainly mediated by Mrp2 (Takashima …
11C-PK11195 PET for the in vivo evaluation of neuroinflammation in the rat brain after cortical spreading depression
Y Cui, T Takashima, M Takashima-Hirano… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Neurogenic inflammation triggered by extravasation of plasma protein has been hypothesized
as a key factor in the generation of the pain sensation associated with migraine. The …
as a key factor in the generation of the pain sensation associated with migraine. The …
Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs
…, K Rockich, K Taskar, T Takashima… - Clinical and …, 2022 - Wiley Online Library
The accurate prediction of OATP1B‐mediated drug–drug interactions (DDIs) is challenging
for drug development. Here, we report a physiologically‐based pharmacokinetic (PBPK) …
for drug development. Here, we report a physiologically‐based pharmacokinetic (PBPK) …
General Method for the 11C‐Labeling of 2‐Arylpropionic Acids and Their Esters: Construction of a PET Tracer Library for a Study of Biological Events Involved in …
M Takashima‐Hirano, M Shukuri… - … A European Journal, 2010 - Wiley Online Library
Cyclooxygenase (COX) is a critical enzyme in prostaglandin biosynthesis that modulates a
wide range of biological functions, such as pain, fever, and so on. To perform in vivo COX …
wide range of biological functions, such as pain, fever, and so on. To perform in vivo COX …
The Involvement of Organic Anion Transporting Polypeptide in the Hepatic Uptake of Telmisartan in Rats: PET Studies with [11C]Telmisartan
T Takashima, Y Hashizume, Y Katayama… - Molecular …, 2011 - ACS Publications
Telmisartan, a selective angiotensin II receptor antagonist, is primarily excreted via
hepatobiliary transport. The predominant contribution of organic anion transporting polypeptide (…
hepatobiliary transport. The predominant contribution of organic anion transporting polypeptide (…
[HTML][HTML] Association between aromatase in human brains and personality traits
K Takahashi, T Hosoya, K Onoe, T Takashima… - Scientific Reports, 2018 - nature.com
Aromatase, an enzyme that converts androgens to estrogens, has been reported to be involved
in several brain functions, including synaptic plasticity, neurogenesis, neuroprotection, …
in several brain functions, including synaptic plasticity, neurogenesis, neuroprotection, …