Key factors that contribute to the aerodynamic properties of aerosol particles are found in
Stokes' law. These factors may be monitored or controlled to optimize drug delivery to the lungs…

… TB Martonen. Aerosol therapy implications of particle deposition patterns in simulated human
… TB Martonen. Analytical model of hygroscopic particle behavior in human airways. Bull. …

… on downstream flow fields and deposition in the upper TB region. Recent deposition
studies that have incorporated some form of the larynx include Martonen et al. (48), Zhang and …

… MA Dolovich, NR MacIntyre, PJ Anderson, CA Camargo Jr, N Chew, CH Cole, R Dhand,
JB Fink, NJ Gross, DR Hess, AJ Hickey, CS Kim, TB Martonen, DJ Pierson, BK Rubin, GC …

To accurately assess the potential therapeutic effects of airborne drugs, the deposition sites
of inhaled particles must be known. Herein, an original theory is presented for …

… Deposition in the TB airways increased slightly with tidal volume due to the increased … For
MMADs of 2 and 3 μm, deposition in the TB region becomes more pronounced because larger …

… TB Martonen. Analytical model of hygroscopic particle behavior in human airways. Bull. …
TB Martonen. On the fate of inhaled particles in the human, a comparison of experimental data …

A model is developed to calculate the deposition of hygroscopic aerosols in the human
tracheobronchial (TB) tree. The TB airflow pattern assumed is consistent with experimental …

… elsewhere (Martonen et al., 1988; Hofmann et al., 1988). In Figure 8 we present a comparison
of TB deposition … It is interesting that the difference between the two TB models is more …

The deposition sites of inhaled particles must be known to (1) promote therapeutic effects of
airborne pharmacologic drugs via targeted delivery and (2) improve risk assessments of …