Background Cetuximab is effective in platinum-resistant recurrent or metastatic squamous-cell
carcinoma of the head and neck. We investigated the efficacy of cetuximab plus platinum-…

Background Previous trials have shown that anti-EGFR monoclonal antibodies can improve
clinical outcomes of patients with recurrent or metastatic squamous-cell carcinoma of the …

Importance In clinical practice, patients with primary metastatic renal cell carcinoma (mRCC)
have been offered cytoreductive nephrectomy (CN) followed by targeted therapy, but the …

Background Trastuzumab duocarmazine is a novel HER2-targeting antibody–drug conjugate
comprised of trastuzumab covalently bound to a linker drug containing duocarmycin. …

Purpose Inactivation of the von Hippel-Lindau gene in clear-cell renal cell carcinomas (RCC)
leads to overexpression of hypoxia inducible factor, a transcription factor regulating …

Background Infections with SARS-CoV-2 continue to cause significant morbidity and mortality.
Interleukin (IL)-1 and IL-6 blockade have been proposed as therapeutic strategies in …

The two isoforms cyclooxygenase-1 and -2 catalyze the initial step in the formation of
prostaglandins in a variety of pathophysiological processes. More recently their role in …

Background Most trials in head and neck cancer emphasize locoregional control, as this is
the main pattern of therapy failure. However, up to 15% of patients develop distant metastases…

Background The phase III EXTREME study demonstrated that combining cetuximab with
platinum/5-fluorouracil (5-FU) significantly improved overall survival in the first-line treatment of …

Over the last decades, advances in the knowledge of immunology have led to the identification
of immune checkpoints, reinvigorating cancer immunotherapy. Although normally …