Imaging β-amyloid burden in aging and dementia

CC Rowe, S Ng, U Ackermann, SJ Gong, K Pike… - Neurology, 2007 - AAN Enterprises
Objective: To compare brain β-amyloid (Aβ) burden measured with [ 11 C]Pittsburgh Compound
B (PIB) PET in normal aging, Alzheimer disease (AD), and other dementias. Methods: …

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

…, A Rigopoulos, GA Cartwright, G O'Keefe, S Gong… - Brain, 2011 - academic.oup.com
While considerable effort has focused on developing positron emission tomography β-amyloid
imaging radiotracers for the early diagnosis of Alzheimer's disease, no radiotracer is …

Visual assessment versus quantitative assessment of 11C-PIB PET and 18F-FDG PET for detection of Alzheimer's disease

…, S Berlangieri, ST Lee, M Cherk, SJ Gong… - Journal of nuclear …, 2007 - Soc Nuclear Med
Amyloid-β (Aβ) imaging with N-methyl- 11 C-2-(4′-methylamino-phenyl)-6-hydroxy-benzothiazole
( 11 C-6-OH-BTA-1; also known as 11 C-PIB) shows a robust increase in cortical …

11C-PIB binding is increased in patients with cerebral amyloid angiopathy–related hemorrhage

…, VL Villemagne, JA Zavala, H Ma, G O'Keefe, SJ Gong… - Neurology, 2010 - AAN Enterprises
Background: The in vivo diagnosis of cerebral amyloid angiopathy (CAA) is inferred from
clinical and structural imaging features. C-Pittsburgh compound B (PIB) is a PET ligand that …

Hypoxia-targeted radiotherapy dose painting for head and neck cancer using 18F-FMISO PET: A biological modeling study

…, NJ Anderson, D Lim Joon, ST Lee, SJ Gong… - Acta …, 2013 - Taylor & Francis
Background. This study investigates the use of 18 F-fluoromisonidazole (FMISO) PET-guided
radiotherapy dose painting for potentially overcoming the radioresistant effects of hypoxia …

[HTML][HTML] Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

…, L Tögel, A Rigopoulos, SJ Gong… - Nature …, 2019 - nature.com
Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in
multiple tissues, however its role in regulating lipid metabolism in the intestinal epithelium is …

Radiation dosimetry of β-amyloid tracers 11C-PiB and 18F-BAY94-9172

…, HJ Tochon-Danguy, JG Chan, S Gong… - Journal of Nuclear …, 2009 - Soc Nuclear Med
β-Amyloid (Aβ) imaging has great potential to aid in the diagnosis of Alzheimer disease and
the development of therapeutics. The radiation dosimetry of Aβ radioligands may influence …

[HTML][HTML] Molecular imaging of T cell co-regulator factor B7-H3 with 89Zr-DS-5573a

…, Z Liu, HK Gan, A Rigopoulos, GJ O'Keefe, SJ Gong… - Theranostics, 2018 - ncbi.nlm.nih.gov
B7-H3 is a transmembrane protein widely expressed in a variety of cancers and has been
shown to play a role in anti-tumor immunity. This study aims to develop a molecular imaging …

A novel method for respiratory motion gated with geometric sensitivity of the scanner in 3D PET

J He, GJ O'Keefe, SJ Gong, G Jones… - IEEE transactions on …, 2008 - ieeexplore.ieee.org
PET image quality can be significantly affected by respiratory motion artifacts. To improve
image quality, surveillance systems have been developed to track the movements of the …

[HTML][HTML] Physiological and transcriptomic effects of hexafluoropropylene oxide dimer acid in Caenorhabditis elegans during development

Z Feng, F McLamb, JP Vu, S Gong… - Ecotoxicology and …, 2022 - Elsevier
Per- and polyfluoroalkyl substances (PFAS) are chemicals resistant to degradation. While
such a feature is desirable in consumer and industrial products, some PFAS, including …