Efficacy and safety of avapritinib in previously treated patients with advanced systemic mastocytosis

…, O Hermine, I Dybedal, HM Lin, SN Rylova… - Blood …, 2022 - ashpublications.org
Advanced systemic mastocytosis (AdvSM) is a rare myeloid neoplasm, driven by the KIT
D816V mutation in >90% of patients. Avapritinib, a potent, highly selective D816V-mutant KIT …

The CLN3 Gene is a Novel Molecular Target for Cancer Drug Discovery

SN Rylova, A Amalfitano, DA Persaud-Sawin, WX Guo… - Cancer research, 2002 - AACR
Juvenile Batten disease is a neurodegenerative disease caused by accelerated apoptotic
death of photoreceptors and neurons attributable to defects in the CLN3 gene. CLN3 is …

Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3‐and CLN2‐deficient neurons

S Dhar, RL Bitting, SN Rylova… - Annals of Neurology …, 2002 - Wiley Online Library
Multiple gene defects cause Batten disease. Accelerated apoptosis accounts for neurodegeneration
in the late infantile and juvenile forms that are due to defects in the CLN3 and CLN2 …

[HTML][HTML] The somatostatin receptor 2 antagonist 64Cu-NODAGA-JR11 outperforms 64Cu-DOTA-TATE in a mouse xenograft model

SN Rylova, C Stoykow, L Del Pozzo, K Abiraj… - PLoS …, 2018 - journals.plos.org
Copper-64 is an attractive radionuclide for PET imaging and is frequently used in clinical
applications. The aim of this study was to perform a side-by-side comparison of the in vitro and …

Does imaging αvβ3 integrin expression with PET detect changes in angiogenesis during bevacizumab therapy?

SN Rylova, E Barnucz, M Fani, F Braun… - Journal of Nuclear …, 2014 - Soc Nuclear Med
In recent years, there has been a growing interest in molecular imaging markers of tumor-induced
angiogenesis. Several radiolabeled RGD (arginine, glycine, aspartate) peptides have …

Immuno-PET imaging of CD30-positive lymphoma using 89Zr-desferrioxamine–labeled CD30-specific AC-10 antibody

SN Rylova, L Del Pozzo, C Klingeberg… - Journal of Nuclear …, 2016 - Soc Nuclear Med
The CD30-specific antibody–drug conjugate, brentuximab vedotin, is approved for the
treatment of relapsed, refractory Hodgkin lymphomas and systemic anaplastic large T-cell …

[HTML][HTML] Radioiodinated exendin-4 is superior to the radiometal-labelled glucagon-like peptide-1 receptor probes overcoming their high kidney uptake

…, J Eersels, PT Meyer, HR Maecke, SN Rylova - PLoS …, 2017 - journals.plos.org
GLP-1 receptors are ideal targets for preoperative imaging of benign insulinoma and for
quantifying the beta cell mass. The existing clinical tracers targeting GLP-1R are all agonists …

Approaches to improve the pharmacokinetics of radiolabeled glucagon-like peptide-1 receptor ligands using antagonistic tracers

SN Rylova, B Waser, L Del Pozzo… - Journal of Nuclear …, 2016 - Soc Nuclear Med
The glucagon-like peptide-1 (GLP-1) receptors are important biomarkers for imaging pancreatic
β-cell mass and detection of benign insulinomas. Using GLP-1 receptor antagonists, we …

Activity profiles of deoxynucleoside kinases and 5′-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside …

SN Rylova, F Albertioni, G Flygh, S Eriksson - Biochemical pharmacology, 2005 - Elsevier
Nucleoside reverse transcriptase inhibitor (NRTI) treatment of HIV is associated with
complications, including lipodystrophy (LD) and myopathy. Inhibition of mitochondrial DNA …

[HTML][HTML] The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist

K Abiraj, S Ursillo, ML Tamma, SN Rylova, B Waser… - EJNMMI research, 2018 - Springer
Background Somatostatin receptor targeting radiopeptides are successfully being used to
image, stage, and monitor patients with neuroendocrine tumours. They are exclusively …