Expression of the epithelial-specific integrin α v β 6 is low or undetectable in most adult
tissues but may be increased during wound healing and inflammation and is up-regulated …

The cell surface receptor α v β 6 is epithelial specific, and its expression is tightly regulated;
it is low or undetectable in adult tissues but has been shown to be increased in many …

Purpose: The study was undertaken to develop and evaluate the potential of an integrin α v β
6 -binding peptide (α v β 6 -BP) for noninvasive imaging of a diverse range of malignancies …

Numerous radiolabeled peptides have been utilized for in vivo imaging of a variety of cell
surface receptors. For applications in PET using [ 18 F]fluorine, peptides are radiolabeled via a …

INTRODUCTION: Click chemistry, particularly the Huisgen 1,3-dipolar cycloaddition of an
alkyne with an azide, has quickly become popular for site-specific radiolabeling. Recently, …

Many anticancer drugs exhibit high systemic off-target toxicities causing severe side effects.
Peptide–drug conjugates (PDCs) that target tumor-specific receptors such as integrin α v β 6 …

The rapid development and translation of targeted molecular imaging agents from bench to
bedside is currently a slow process, with a clear bottleneck between the discovery of new …

The strain-promoted click 1,3-dipolar cycloaddition reactions involving azides and
cyclooctynes for the synthesis of triazoles offer the advantage of being able to be performed in …

Radiotracers based on the peptide A20FMDV2 selectively target the cell surface receptor
integrin α v β 6 . This integrin has been identified as a prognostic indicator correlating with the …

Significant upregulation of the integrin α v β 6 has been described as a prognostic indicator
in several cancers, making it an attractive target for tumor imaging. This study compares …