The reference tissue model allows for quantification of receptor kinetics without measuring
the arterial input function, thus avoiding arterial cannulation and time-consuming metabolite …

A method is presented for the generation of parametric images of radioligand–receptor binding
using PET. The method is based on a simplified reference region compartmental model, …

[Carbonyl- 11 C]WAY-100635 is a promising PET radioligand for the 5-HT 1A receptor,
having demonstrated more favorable characteristics forin vivoimaging than the previously …

With the stated aim of scanning small regions of interest in mice, several high-resolution
positron emission tomographic (PET) systems are presently under development. Some, however…

The enantiomers of [N-methyl- 11 C]PK 11195, a radioligand for PET studies of PK (peripheral
benzodiazepine) binding sites, have been prepared from the newly synthesized N-…

Using conventional autoradiographic and tissue counting techniques, the experimental
quantitation of in vivo kinetics of prospective or established radioligands for PET is animal and …

The regional binding of the opiate receptor ligand diprenorphine has been examined in rat
brain both in vivo and in vitro. The time course of total label in specific brain regions was …

The 5-HT 1A receptor antagonist, WAY-100635 [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridyl)
cyclohexanecarboxamide], was labelled in its carbonyl group with carbon-…

There is evidence of marked variation in the brain distribution of specific subtypes of the
GABA-benzodiazepine receptor and that particular subtypes mediate different functions. The α5-…

The selective 5-HT 1A receptor radioligand, [ 11 C]WAY-100635 {[ 11 C]N-2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2-pyridyl)cyclohexanecarboxamide},
has been injected …