Age-related loss of brain tissue has been inferred from cross-sectional neuroimaging studies,
but direct measurements of gray and white matter changes from longitudinal studies are …

Objective To determine whether hearing loss is associated with incident all-cause dementia
and Alzheimer disease (AD). Design Prospective study of 639 individuals who underwent …

• Unmedicated schizophrenic patients (according toDSM-III-Rcriteria) (n = 36) and age-matched
normal controls (n = 36), balanced for parental socioeconomic status, were …

Background Serum testosterone concentrations decrease as men age, but benefits of raising
testosterone levels in older men have not been established. Methods We assigned 790 …

Objective: To determine the relationship between hearing loss and cognitive function as
assessed with a standardized neurocognitive battery. We hypothesized a priori that greater …

Longitudinal studies indicate that declines in cognition and memory accelerate after age 70
years. The neuroanatomic and neurophysiologic underpinnings of cognitive change are …

Importance Older adults commonly report disturbed sleep, and recent studies in humans
and animals suggest links between sleep and Alzheimer disease biomarkers. Studies are …

A prospective sample of 69 healthy adults, age range 18-80 years, was studied with magnetic
resonance imaging scans (T2 weighted, 5 mm thick) of the entire cranium. Volumes were …

… *Address all correspondence and requests for reprints to: Susan M. Resnick, Ph.D., National
Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, …

Hearing impairment in older adults is independently associated in longitudinal studies with
accelerated cognitive decline and incident dementia, and in cross-sectional studies, with …