Background Preclinical and preliminary clinical data indicate that ch14.18, a monoclonal
antibody against the tumor-associated disialoganglioside GD2, has activity against …

Background Paediatric low-grade glioma is the most common CNS tumour of childhood.
Although overall survival is good, disease often recurs. No single universally accepted …

Background Myeloablative chemoradiotherapy and immunomagnetically purged autologous
bone marrow transplantation has been shown to improve outcome for patients with high-…

Purpose Children diagnosed at age≥ 18 months with metastatic MYCN-nonamplified
neuroblastoma (NBL-NA) are at high risk for disease relapse, whereas those diagnosed at age< …

Importance Induction chemotherapy followed by high-dose therapy with autologous stem cell
transplant and subsequent antidisialoganglioside antibody immunotherapy is standard of …

PURPOSE We sought to identify factors assessable at the time of admission for fever and
neutropenia that predict bacteremia in children with cancer. PATIENTS AND METHODS One …

Radiolabeled metaiodobenzylguanidine (mIBG) is a highly sensitive and specific marker for
detecting neuroblastoma. A semiquantitative mIBG score (Curie score [CS]) was assessed …

Purpose Platinum-based therapy is the mainstay for management of high-risk neuroblastoma.
Prevalence of platinum-related ototoxicity has ranged from 13% to 95% in previous reports…

Purpose This analysis of patients in the Children’s Oncology Group A3973 study evaluated
the impact of extent of primary tumor resection on local progression and survival and …

LBA3 Background: ASCT improves event-free survival (EFS) for HR-NB. Pilot studies suggest
that intensification of myeloablative therapy using tandem ASCT further improves outcome …