User profiles for Sunil Singhal

Sunil Singhal

Associate Professor, University of Pennsylvania
Verified email at uphs.upenn.edu
Cited by 15164

Nanotechnology applications in surgical oncology

S Singhal, S Nie, MD Wang - Annual review of medicine, 2010 - annualreviews.org
Surgery is currently the most effective and widely used procedure in treating human cancers,
and the single most important predictor of patient survival is a complete surgical resection. …

Intraoperative near-infrared imaging can identify pulmonary nodules

…, K Oh, M Wang, SM Albelda, S Nie, S Singhal - The Annals of thoracic …, 2014 - Elsevier
Background Over 80,000 people undergo pulmonary resection for a lung nodule in the
United States each year. Small nodules are frequently missed or difficult to find despite …

Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration

AM Mohs, MC Mancini, S Singhal… - Analytical …, 2010 - ACS Publications
Surgery is one of the most effective and widely used procedures in treating human cancers,
but a major problem is that the surgeon often fails to remove the entire tumor, leaving behind …

Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non–small cell lung cancer: a review

S Singhal, A Vachani, D Antin-Ozerkis, LR Kaiser… - Clinical Cancer …, 2005 - AACR
Lung cancer is the leading cause of cancer death in the US with survival restricted to a
subset of those patients able to undergo surgical resection. However, even with surgery, …

[PDF][PDF] Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer

S Singhal, PS Bhojnagarwala, S O'Brien, EK Moon… - Cancer cell, 2016 - cell.com
Based on studies in mouse tumor models, granulocytes appear to play a tumor-promoting
role. However, there are limited data about the phenotype and function of tumor-associated …

Evolving options in the management of esophageal perforation

CJ Brinster, S Singhal, L Lee, MB Marshall… - The Annals of thoracic …, 2004 - Elsevier
Esophageal perforation remains a devastating event that is difficult to diagnose and manage.
The majority of injuries are iatrogenic and the increasing use of endoscopic procedures …

[HTML][HTML] Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

…, M Feldman, SM Albelda, S Singhal - The Journal of …, 2014 - Am Soc Clin Investig
Infiltrating inflammatory cells are highly prevalent within the tumor microenvironment and
mediate many processes associated with tumor progression; however, the contribution of …

[HTML][HTML] Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils

ZG Fridlender, J Sun, I Mishalian, S Singhal, G Cheng… - PloS one, 2012 - journals.plos.org
The role of myeloid cells in supporting cancer growth is well established. Most work has focused
on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, …

[HTML][HTML] Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice

…, D Smirnov, MA Sepulveda, S Singhal… - Journal of Experimental …, 2021 - rupress.org
Disclosures: V. Bhargava is a full-time employee of Janssen Research and Development LLC.
J. Patel and P. Wilkinson are employees of Janssen Research and Development LLC. D. …

Neutrophils recruit regulatory T‐cells into tumors via secretion of CCL17—A new mechanism of impaired antitumor immunity

…, L Levy, L Zolotarov, S Singhal… - … journal of cancer, 2014 - Wiley Online Library
The mechanisms by which tumor‐associated neutrophils (TANs) affect tumor growth are to
a large extent unknown. Regulatory T‐cells (T‐regs) are functionally immune‐suppressive …