User profiles for Sunil Singhal
Sunil SinghalAssociate Professor, University of Pennsylvania Verified email at uphs.upenn.edu Cited by 15164 |
Nanotechnology applications in surgical oncology
Surgery is currently the most effective and widely used procedure in treating human cancers,
and the single most important predictor of patient survival is a complete surgical resection. …
and the single most important predictor of patient survival is a complete surgical resection. …
Intraoperative near-infrared imaging can identify pulmonary nodules
Background Over 80,000 people undergo pulmonary resection for a lung nodule in the
United States each year. Small nodules are frequently missed or difficult to find despite …
United States each year. Small nodules are frequently missed or difficult to find despite …
Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration
Surgery is one of the most effective and widely used procedures in treating human cancers,
but a major problem is that the surgeon often fails to remove the entire tumor, leaving behind …
but a major problem is that the surgeon often fails to remove the entire tumor, leaving behind …
Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non–small cell lung cancer: a review
Lung cancer is the leading cause of cancer death in the US with survival restricted to a
subset of those patients able to undergo surgical resection. However, even with surgery, …
subset of those patients able to undergo surgical resection. However, even with surgery, …
[PDF][PDF] Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer
S Singhal, PS Bhojnagarwala, S O'Brien, EK Moon… - Cancer cell, 2016 - cell.com
Based on studies in mouse tumor models, granulocytes appear to play a tumor-promoting
role. However, there are limited data about the phenotype and function of tumor-associated …
role. However, there are limited data about the phenotype and function of tumor-associated …
Evolving options in the management of esophageal perforation
CJ Brinster, S Singhal, L Lee, MB Marshall… - The Annals of thoracic …, 2004 - Elsevier
Esophageal perforation remains a devastating event that is difficult to diagnose and manage.
The majority of injuries are iatrogenic and the increasing use of endoscopic procedures …
The majority of injuries are iatrogenic and the increasing use of endoscopic procedures …
[HTML][HTML] Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer
Infiltrating inflammatory cells are highly prevalent within the tumor microenvironment and
mediate many processes associated with tumor progression; however, the contribution of …
mediate many processes associated with tumor progression; however, the contribution of …
[HTML][HTML] Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils
ZG Fridlender, J Sun, I Mishalian, S Singhal, G Cheng… - PloS one, 2012 - journals.plos.org
The role of myeloid cells in supporting cancer growth is well established. Most work has focused
on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, …
on myeloid-derived suppressor cells (MDSC) that accumulate in tumor-bearing animals, …
[HTML][HTML] Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice
…, D Smirnov, MA Sepulveda, S Singhal… - Journal of Experimental …, 2021 - rupress.org
Disclosures: V. Bhargava is a full-time employee of Janssen Research and Development LLC.
J. Patel and P. Wilkinson are employees of Janssen Research and Development LLC. D. …
J. Patel and P. Wilkinson are employees of Janssen Research and Development LLC. D. …
Neutrophils recruit regulatory T‐cells into tumors via secretion of CCL17—A new mechanism of impaired antitumor immunity
The mechanisms by which tumor‐associated neutrophils (TANs) affect tumor growth are to
a large extent unknown. Regulatory T‐cells (T‐regs) are functionally immune‐suppressive …
a large extent unknown. Regulatory T‐cells (T‐regs) are functionally immune‐suppressive …