Learned associations between effects of abused drugs and the drug administration environment
are important in drug addiction. Histochemical and electrophysiological studies suggest …

Numerous human tumor types, including ovarian cancer, display a significant expression of
the CD44 family of cell surface proteoglycans. To develop tumortargeted drugs, we have …

Introduction: Advances in cancer therapeutics, namely more effective and less toxic treatments,
will occur with targeting strategies that enhance the tumor biodistribution and thwart …

Gastrointestinal cancer is one of the leading causes of cancer-related mortality in men and
women worldwide. The adult stem cell marker LGR5 (leucine-rich repeat-containing, G protein…

Introduction Bifunctional chelators have been shown to impact the biodistribution of
monoclonal antibody (mAb)-based imaging agents. Recently, radiolabeled 1,4,7-triazacyclononane,1…

The presence of brown adipose tissue responsible for thermogenic energy dissipation has
been revealed in adult humans and has high clinical importance. Owing to limitations of …

Purpose: Most primary human ovarian tumors and peritoneal implants, as well as tumor
vascular endothelial cells, express the CD44 family of cell surface proteoglycans, the natural …

Chemotherapeutic regimens incorporating taxanes significantly improve outcomes for patients
with squamous cell carcinomas of the head and neck (SCCHN). However, treatment with …

Intraoperative detection of tumors has had a profound impact on how cancer surgery is
performed and addresses critical unmet needs in surgical oncology. Tumor deposits, margins, …

Dye design can influence the ability of fluorescently labeled imaging agents to generate
tumor contrast and has become an area of significant interest in the field of fluorescence-guided …