Membrane receptors and ion transport mechanisms probably have an important role in
lymphocyte activation leading to T-lymphocyte proliferation in the immune response. Here we …

… Graham Pawelec1, Yvonne Barnett2, Ros Forsey3, Daniela Frasca4, Amiela Globerson5,
Julie McLeod6, Calogero Caruso7, Claudio Franceschi8, Támás Fülöp9, Sudhir Gupta10 …

Aging represents a state of paradox where chronic inflammation is associated with declining
immune responses. Dendritic cells (DCs) are the major APCs responsible for initiating an …

Background Predicted increases in suicide were not generally observed in the early months
of the COVID-19 pandemic. However, the picture may be changing and patterns might vary …

In recent years major progress has been made in understanding the molecular steps of death
receptor and mitochondrial pathway of apoptosis. Mechanisms of NF-κB-mediated survival …

Background There is uncertainty about the impact of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection in individuals with rare inborn errors of immunity (IEI), a …

Th1-like (IL-2, IFN-γ) and Th2-like (IL-4, IL-6, and IL-10) cytokines were examined in CD4 +
and CD8 + T cells in children with autism. Intracellular cytokines were measured using …

In almost all multicellular organisms, cell suicide or apoptosis appears to play an important
role in the maintenance of cellular homeostasis. Apoptosis is tightly regulated by a set of …

Aging is characterized by increased T cell lymphopenia, T cell dysfunction, and increased
serum TNF levels. In this study, we have examined the role of TNF-induced apoptosis in T cell …

Leptin, one of the adipokines, functions as a hormone and a cytokine. In this investigation,
we show for the first time that leptin, in a concentration-dependent manner, activates human …